0000000000249529

AUTHOR

Sylvie Reveneau

showing 1 related works from this author

Tumour-derived and host-derived nitric oxide differentially regulate breast carcinoma metastasis to the lungs.

2004

To study the role of nitric oxide (NO) in lung metastasis of breast carcinoma, we isolated two cell clones (H and J) from the parental EMT-6 murine breast carcinoma cell line, based on their differential NO production. In vitro, EMT-6 J cells, but not EMT-6H cells, constitutively expressed inducible NO synthase (NOS II) and secreted high levels of NO. IL-1beta increased NO production in both clones, and TNF-alpha had a synergistic effect on IL-1beta-induced NO production, but NO production by EMT-6 J cells was always higher than by EMT-6H cells. Proliferation, survival and adhesion to lung-derived endothelial cells of both clones were similar and were not affected by NO. In vivo, both clone…

Cancer ResearchPathologymedicine.medical_specialtyLung NeoplasmsCell SurvivalCellNitric Oxide Synthase Type IINitric OxideGuanidinesNitric oxideMetastasischemistry.chemical_compoundMiceCarcinomamedicineCell AdhesionTumor Cells CulturedAnimalsEnzyme InhibitorsCell adhesionMice KnockoutMice Inbred BALB CbiologyIndium RadioisotopesEndothelial CellsMammary Neoplasms ExperimentalGeneral Medicinemedicine.diseaseIn vitroNitric oxide synthaseMice Inbred C57BLSurvival Ratemedicine.anatomical_structurechemistryCell cultureembryonic structuresCancer researchbiology.proteinFemaleNitric Oxide SynthaseCell DivisionAnimals/Cell Adhesion/Cell Division/Cell Survival/Endothelial Cells/metabolism/Pathology/Enzyme Inhibitors/pharmacology/Female/Guanidines/Indium Radioisotopes/Interleukin-1/Lung Neoplasms/enzymology/secondary/Mammary NeoplasmsExperimental/Mice/MiceInbred BALB C/MiceInbred C57BL/MiceKnockout/Nitric Oxide/physiology/Nitric Oxide Synthase/antagonists & inhibitors/Nitric Oxide Synthase Type II/Survival Rate/Tumor CellsCulturedInterleukin-1Carcinogenesis
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