0000000000249754

AUTHOR

David Fisas

showing 2 related works from this author

Hormonal and lifestyle factors as modifiers of risk of breast cancer (BC) in BRCA1 and BRCA2 carriers (C).

2015

1560 Background: Mutations in the BRCA1/2 genes confer a high lifetime risk of BC. Penetrance varies among populations and individuals suggesting that non-genetic factors may modify the inherited r...

GeneticsOncologyCancer Researchmedicine.medical_specialtybusiness.industrymedicine.diseasePenetranceBreast cancerLifestyle factorsOncologyInternal medicinemedicineLifetime riskbusinessHormoneJournal of Clinical Oncology
researchProduct

Effects of lifestyle and diet as modifiers of risk of breast cancer (BC) in BRCA1 and BRCA2 carriers.

2017

1505 Background: Mutations in the BRCA1/2 genes confer a high lifetime risk of BC. Penetrance varies among populations and individuals suggesting that non-genetic factors may modify the inherited risk. Knowledge of modifiable factors will help to develop preventive strategies. Methods: Information on physical activity (PA) (current PA and in the adolescence) and smoking was collected in 892 women (W) with a BRCA1/BRCA2 germ-line mutation (582 with BC, 45,62% BRCA2) from 279 families, followed at three Spanish Genetic Counseling Units, 481of these W also answered a food frequency questionnaire. Participants gave their consent and the study was approved by the ethics committee. The associati…

GerontologyCancer Researchbusiness.industryGenetic counselingPhysical activityEthics committeemedicine.diseaseLogistic regressionPenetranceLifestyle factorsBreast cancerOncologyMedicineLifetime riskbusinessDemographyJournal of Clinical Oncology
researchProduct