0000000000252123
AUTHOR
Christian Schroeder
Measurement of inclusive jet charged-particle fragmentation functions in Pb+Pb collisions at sNN=2.76 TeV with the ATLAS detector
Measurements of charged-particle fragmentation functions of jets produced in ultra-relativistic nuclear collisions can provide insight into the modification of parton showers in the hot, dense medi ...
Search for Higgs bosons decaying toaain theμμττfinal state inppcollisions ats=8 TeVwith the ATLAS experiment
A search for the decay to a pair of new particles of either the 125 GeV Higgs boson (h) or a second charge parity (CP)-even Higgs boson (H) is presented. The data set corresponds to an integrated luminosity of 20.3 fb(-1) of pp collisions at root s = 8 TeV recorded by the ATLAS experiment at the LHC in 2012. The search was done in the context of the next-to-minimal supersymmetric standard model, in which the new particles are the lightest neutral pseudoscalar Higgs bosons (a). One of the two a bosons is required to decay to two muons while the other is required to decay to two tau leptons. No significant excess is observed above the expected backgrounds in the dimuon invariant mass range fr…
Search for new phenomena in events with a photon and missing transverse momentum inppcollisions ats=8 TeVwith the ATLAS detector
© 2015 CERN. © 2015 CERN, for the ATLAS Collaboration. Published by the American Physical Society under the terms of the »http://creativecommons.org/licenses/by/3.0/» Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Results of a search for new phenomena in events with an energetic photon and large missing transverse momentum with the ATLAS experiment at the LHC are reported. Data were collected in proton-proton collisions at a center-of-mass energy of 8 TeV and correspond to an integrated luminosity of 20.3 fb-1. The observed data are well described by the expe…
Identification of Morphological Biosignatures in Martian Analogue Field Specimens Using In Situ Planetary Instrumentation
International audience; We have investigated how morphological biosignatures (i.e., features related to life) might be identified with an array of viable instruments within the framework of robotic planetary surface operations at Mars. This is the first time such an integrated lab-based study has been conducted that incorporates space-qualified instrumentation designed for combined in situ imaging, analysis, and geotechnics ( sampling). Specimens were selected on the basis of feature morphology, scale, and analogy to Mars rocks. Two types of morphological criteria were considered: potential signatures of extinct life ( fossilized microbial filaments) and of extant life (crypto-chasmoendolit…
Search for an excess of events with an identical flavour lepton pair and significant missing transverse momentum in root s=7 TeV proton-proton collisions with the ATLAS detector
Results are presented of a search for supersymmetric particles decaying into final states with significant missing transverse momentum and exactly two identical flavour leptons (e or mu) of opposite charge in sqrt{s}=7 TeV collisions at the Large Hadron Collider. This channel is particularly sensitive to supersymmetric particle cascade decays producing flavour correlated lepton pairs. Flavour uncorrelated backgrounds are subtracted using a sample of opposite flavour lepton pair events. Observation of an excess beyond Standard Model expectations following this subtraction procedure would offer one of the best routes to measuring the masses of supersymmetric particles. In a data sample corres…
Subtype-Specific Desensitization of Human Endothelin ETA and ETB Receptors Reflects Differential Receptor Phosphorylation
Endothelins regulate blood pressure in mammals through G protein-coupled receptors. Two receptor subtypes, ETA and ETB, exist which differ by their agonist profiles. Here we show subtype-specific differences in the inactivation of these endothelin receptors. Using a modified inositol phosphate accumulation assay, we found that stimulation of ETA by endothelin-1 results in sustained activation of the subtype, retaining >30% of its initial activity even 20 min after agonist administration, whereas the ETB rapidly deactivated after agonist stimulation, losing >80% of its initial activity within 5 min after endothelin application. The discrepancy in receptor inactivation is reflected by subtype…
Measurements ofWγandZγproduction inppcollisions ats=7 TeVwith the ATLAS detector at the LHC
The integrated and differential fiducial cross sections for the production of a W or Z boson in association with a high-energy photon are measured using pp collisions at root s = 7 TeV. The analyse ...
Measurements of the Total and Differential Higgs Boson Production Cross Sections Combining theH→γγandH→ZZ*→4ℓDecay Channels ats=8 TeVwith the ATLAS Detector
Measurements of the total and differential cross sections of Higgs boson production are performed using 20.3 fb(-1) of pp collisions produced by the Large Hadron Collider at a center-of-mass energy of root s = 8 TeV and recorded by the ATLAS detector. Cross sections are obtained from measured H -> gamma gamma and H -> ZZ*. 4l event yields, which are combined accounting for detector efficiencies, fiducial acceptances, and branching fractions. Differential cross sections are reported as a function of Higgs boson transverse momentum, Higgs boson rapidity, number of jets in the event, and transverse momentum of the leading jet. The total production cross section is determined to be sigma(pp -> …
Subtype-specific endothelin-A and endothelin-B receptor desensitization correlates with differential receptor phosphorylation.
In the rat cardiovascular system endothelin-1 (ET-1) elicits prolonged physiologic responses mediated by the ET A receptor, whereas the effects mediated by the ET B receptor are transient. The molecular mechanisms for the subtype-specific responses are not yet clear. However, post-translational modifications such as phosphorylation and palmitoylation may play an important role. In Sf9 cells overexpressing the human ET A and ET B receptors, both subtypes are palmitoylated. However, only the ET B but not the ET A receptor is phosphorylated in a ligand-dependent manner. Because phosphorylation is believed to play an important role in ligand-dependent receptor inactivation, we analyzed whether …
Palmitoylation of Endothelin Receptor A
Post-translational modifications such as phosphorylation and palmitoylation play important roles for the function and regulation of receptors coupled to heterotrimeric guanyl nucleotide-binding proteins. Here we demonstrate that the human endothelin receptor A (ETA) incorporates [3H]palmitate. Mutation of a cluster of five cysteine residues present in the cytoplasmic tail of ETA into serine or alanine residues completely prevented palmitoylation of the receptor. The ligand binding affinity of the non-palmitoylated ETA mutants was essentially unchanged as compared to the palmitoylated wild type ETA suggesting that the replacement of the cysteine residues did not alter the overall structure o…
Search for vectorlikeBquarks in events with one isolated lepton, missing transverse momentum, and jets ats=8 TeVwith the ATLAS detector
A search has been performed for pair production of heavy vectorlike down-type (B) quarks. The analysis explores the lepton-plus-jets final state, characterized by events with one isolated charged lepton (electron or muon), significant missing transverse momentum, and multiple jets. One or more jets are required to be tagged as arising from b quarks, and at least one pair of jets must be tagged as arising from the hadronic decay of an electroweak boson. The analysis uses the full data sample of pp collisions recorded in 2012 by the ATLAS detector at the LHC, operating at a center-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 20.3 fb(-1). No significant excess of event…
Measurement of Higgs boson production in the diphoton decay channel inppcollisions at center-of-mass energies of 7 and 8 TeV with the ATLAS detector
A measurement of the production processes of the recently discovered Higgs boson is performed in the two-photon final state using 4.5 fb(-1) of proton-proton collisions data at root s = 7 TeV and 20.3 fb(-1) at root s = 8 TeV collected by the ATLAS detector at the Large Hadron Collider. The number of observed Higgs boson decays to diphotons divided by the corresponding Standard Model prediction, called the signal strength, is found to be mu = 1.17 +/- 0.27 at the value of the Higgs boson mass measured by ATLAS, m(H) = 125.4 GeV. The analysis is optimized to measure the signal strengths for individual Higgs boson production processes at this value of m(H). They are found to be mu(ggF) = 1.32…
Measurements of the top quark branching ratios into channels with leptons and quarks with the ATLAS detector
Measurements of the branching ratios of top quark decays into leptons and jets using events with t[bar over t] (top antitop) pairs are reported. Events were recorded with the ATLAS detector at the LHC in pp collisions at a center-of-mass energy of 7 TeV. The collected data sample corresponds to an integrated luminosity of 4.6 fb[superscript −1]. The measured top quark branching ratios agree with the Standard Model predictions within the measurement uncertainties of a few percent.
Measurement of hard double-parton interactions inW(???) + 2-jet events at $\sqrt{s}\,=7$ TeV with the ATLAS detector
The production of W bosons in association with two jets in proton–proton collisions at a centre-of-mass energy of √s=7 TeV has been analysed for the presence of double-parton interactions using data corresponding to an integrated luminosity of 36 pb[superscript −1], collected with the ATLAS detector at the Large Hadron Collider. The fraction of events arising from double-parton interactions, f[superscript (D) over subscript DP], has been measured through the p[subscript T] balance between the two jets and amounts to f[superscript (D) over subscript DP] = 0.08 ± 0.01 (stat.) ± 0.02 (sys.) for jets with transverse momentum p[subscript T] > 20 GeV and rapidity |y| < 2.8. This corresponds to a …
Measurements of spin correlation in top-antitop quark events from proton-proton collisions ats=7 TeVusing the ATLAS detector
Measurements of spin correlation in top quark pair production are presented using data collected with the ATLAS detector at the LHC with proton-proton collisions at a center-of-mass energy of 7 TeV, corresponding to an integrated luminosity of 4.6 fb(-1). Events are selected in final states with two charged leptons and at least two jets and in final states with one charged lepton and at least four jets. Four different observables sensitive to different properties of the top quark pair production mechanism are used to extract the correlation between the top and antitop quark spins. Some of these observables are measured for the first time. The measurements are in good agreement with the Stan…
Search for a Heavy Neutral Particle Decaying toeμ,eτ, orμτinppCollisions ats=8 TeVwith the ATLAS Detector
This Letter presents a search for a heavy neutral particle decaying into an opposite-sign different-flavor dilepton pair, e(+/-) mu(-/+), e(+/-) tau(-/+), or mu(+/-) tau(-/+) using 20.3 fb(-1) of pp collision data at root s = 8 TeV collected by the ATLAS detector at the LHC. The numbers of observed candidate events are compatible with the standard model expectations. Limits are set on the cross section of new phenomena in two scenarios: the production of (nu) over tilde (tau) in R-parity-violating supersymmetric models and the production of a lepton-flavor-violating Z' vector boson.
Measurement of upsilon production in 7 TeV pp collisions at ATLAS
Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM
Overexpression and functional characterization of kinin receptors reveal subtype-specific phosphorylation.
G protein-coupled receptors such as the receptors for bradykinin are present in low copy numbers in most natural cells. To overcome the problems associated with the analysis of these receptors at the protein level, we used highly efficient expression systems such as the baculovirus/insect cell system. However, the structural and functional statuses of recombinant receptors have often remained elusive. We have expressed the two types of human kinin receptors, B1 and B2, in Sf9 cells. Both receptors are found on the surface of infected cells where they display the same pharmacological profiles as their cognate receptors of native cells. The functional analysis of kinin receptors coupled to th…
Coupling of endothelin receptors to the ERK/MAP kinase pathway. Roles of palmitoylation and G(alpha)q.
Endothelins are potent mitogens that stimulate extracellular signal-regulated kinases (ERK/MAP kinases) through their cognate G-protein-coupled receptors, ET(A) and ET(B). To address the role of post-translational ET receptor modifications such as acylation on ERK activation and to identify relevant downstream effectors coupling the ET receptor to the ERK signaling cascades we have constructed a panel of palmitoylation-deficient ET receptor mutants with differential G(alpha) protein binding capacity. Endothelin-1 stimulation of wild-type ET(A) or ET(B) induced a fivefold to sixfold increase in ERK in COS-7 and CHO cells whereas full-length nonpalmitoylated ET(A) and ET(B) mutants failed to …
NOSIP, a novel modulator of endothelial nitric oxide synthase activity.
Production of nitric oxide (NO) in endothelial cells is regulated by direct interactions of endothelial nitric oxide synthase (eNOS) with effector proteins such as Ca2+-calmodulin, by posttranslational modifications such as phosphorylation via protein kinase B, and by translocation of the enzyme from the plasma membrane caveolae to intracellular compartments. Reversible acylation of eNOS is thought to contribute to the intracellular trafficking of the enzyme; however, protein factor(s) that govern the translocation of the enzyme are still unknown. Here we have used the yeast two-hybrid system and identified a novel 34 kDa protein, termed NOSIP (eNOS interacting protein), which avidly binds …
Cloning and Functional Characterization of the Ornithokinin Receptor
Kinins are proinflammatory peptides that dilate vessels, increase vascular permeability, contract smooth muscles, and provoke pain. The known mammalian kinin receptors are classified as two subtypes, i.e. the B1 receptor triggered by [des-Arg9]bradykinin and inhibited by [des-Arg9,Leu8]bradykinin, and the B2 receptor stimulated by bradykinin and antagonized by HOE140. Here we report the cloning of a non-mammalian kinin receptor gene amplified from genomic chicken DNA. The protein predicted from the open reading frame shows 31 and 49% sequence identity to the human B1 and B2 receptors, respectively, suggesting that it represents a G protein-coupled receptor of the kinin receptor family. The …
Simultaneous measurements of thett¯,W+W−, andZ/γ*→ττproduction cross-sections inppcollisions ats=7 TeVwith the ATLAS detector
Simultaneous measurements of the t (t) over bar, W+W-, and Z/gamma* -> tau tau production cross-sections using an integrated luminosity of 4.6 fb(-1) of pp collisions at root s = 7 TeV collected ...
Influence of pre-existing microstructure on mechanical properties of marine ice during compression experiments
AbstractMarine ice is an important component of ice shelves in Antarctica. It accretes in substantial amounts at weak points and below ice shelves. It is likely to exhibit peculiar rheological properties, which are crucial to understanding its potential role in stabilizing ice-shelf flow. Due to its location and consolidation processes, marine ice can present a variety of textures which are likely to influence its rheological properties. We present a new dataset of unconfined uniaxial compression experiments on folded marine ice samples that have been cut at various angles to the folds. Texture and fabric analyses are described ‘before’ and ‘after’ the deformation experiment. It is shown th…
Observation of top-quark pair production in association with a photon and measurement of thett¯γproduction cross section inppcollisions ats=7TeV using the ATLAS detector
A search is performed for top-quark pairs (t (t) over bar) produced together with a photon (gamma) with transverse energy greater than 20 GeV using a sample of t (t) over bar candidate events in final states with jets, missing transverse momentum, and one isolated electron or muon. The data set used corresponds to an integrated luminosity of 4.59 fb(-1) of proton-proton collisions at a center-of-mass energy of 7 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. In total, 140 and 222 t (t) over bar gamma candidate events are observed in the electron and muon channels, to be compared to the expectation of 79 +/- 26 and 120 +/- 39 non-t (t) over bar gamma background events,…
Observation of an Excited $B^{\pm}_c$ Meson State with the ATLAS Detector
A search for excited states of the B±c meson is performed using 4.9 fb-1 of 7 TeV and 19.2 fb-1 of 8 TeV pp collision data collected by the ATLAS experiment at the LHC. A new state is observed through its hadronic transition to the ground state, with the latter detected in the decay B±c→J/ψπ±. The state appears in the m(Bc±π+π-)-m(Bc±)-2m(π±) mass difference distribution with a significance of 5.2 standard deviations. The mass of the observed state is 6842±4±5 MeV, where the first error is statistical and the second is systematic. The mass and decay of this state are consistent with expectations for the second S-wave state of the B±c meson, B±c(2S).