Glycemic variability using 48-hour continuous glucose monitorin, endothelial function, and carotid intima-media thickness in the metabolic syndrome

Glycemic variability using continuous glucose monitoring and endothelial function in the metabolic syndrome and in type 2 diabetes

Aims Subjects who are at increased risk of developing diabetes may have increased glycaemic variability associated with endothelial dysfunction and possibly subclinical atherosclerosis, which may lead to increased cardiovascular risk observed at the time of diabetes diagnosis. To investigate this hypothesis, we measured endothelial function, carotid intima-media thickness and glycaemic variability using 48-h continuous subcutaneous glucose monitoring in 3 groups of overweight or obese subjects – those without the metabolic syndrome, and those with the metabolic syndrome with or without newly diagnosed Type 2 diabetes. Methods Consecutive subjects, aged 30–65 years with a body mass index ‡ 2…

Sarcopenia, sarcopenic obesity and insulin-resistance

Reply to: Letters to the article “Glycaemic variability using continuous glucose monitoring and endothelial function in the metabolic syndrome and in Type 2 diabetes” of Buscemi S. et al. [Diabet. Med. 27, 872–878 (2010)]