Cortical Areas Involved in Vertical Saccades With a 3 Teslas Functional Mri

Circulating plasmalogens in patients with primary open angle glaucoma

Purpose: Neuronal tissues such as the retina contain high amounts of particular phospholipids named “ether-lipids”. Since abnormal blood levels of ether-lipids have been associated with several neurological disorders, we wanted to check whether ether-lipid levels were modified and associated with the severity of POAG. Methods: Blood samples were collected from 41 healthy subjects and 64 POAG patients. Following lipid extraction from erythrocytes, total phospholipids including ether-lipids were isolated using silica cartridges. The fatty acid profile of phospholipids was determined using capillary column gas chromatography (GC). The individual molecular species of phospholipids and ether-lip…

Left minineglect or inverse pseudoneglect in children with dyslexia?

International audience; This study compared the visuospatial asymmetries in children with dyslexia and healthy children by using the manual line bisection task, and investigated the processing of spatial context with a 'local' cueing paradigm consisting of geometric symbols placed on the extremities of the lines. The performance between healthy children (leftward bias) and children with dyslexia (rightward bias) was significantly different. Furthermore, the bisection mark was shifted in the direction of the unilaterally cued extremities in all children. As children with dyslexia showed a rightward bias in their spatial representation, which did not interfere with local context processing, w…

Effect of intravitreal injection of Indocyanine Green, Triamcinolone Acetonide and Trypan Blue on the electroretinographic response of rats

International audience; Purpose:: Indocyanine Green (ICG) and Tripan Blue (TB) are commonly used in macular surgery by making easier the internal limiting membrane (ILM) removing. However, the innocuousness of these dyes is not actually established notably for ICG. Then, several authors proposed the use of triamcinolone acetonide (TA) as an alternative to the use of intraoperative dyes for visualizing the ILM. The purpose of this study was to evaluate the effects of intravitreal injection of ICG, TB and TA on the rat electroretinogram (ERG). Methods:: Three groups of 12-week-old Sprague Dawley rats (n=6) received intravitreal injection in one eye of 0.1mL of either ICG 0.5mg/mL, TB 3mg/mL o…

Ether-lipid and docosahexaenoic acid (DHA) levels in erythrocytes of patients with glaucoma

International audience; Purpose: : Neuronal tissues such as the brain and the retina are known to contain elevated amounts of phospholipids with a vinyl-ether double bond (ether-lipids or plasmalogens) as well as high concentrations of long-chain omega-3 polyunsaturated fatty acids (docosahexaenoic acid or DHA). Abnormal blood levels of ether-lipids and DHA have been associated with several neurological disorders such as Alzheimer Disease. Since many observations bring up the idea of pathogenetic similarities between Alzheimer Disease and glaucoma, the aim of our work was to check whether ether-lipid and DHA levels were modified in glaucoma patients. Methods: : Blood samples were collected …

De novo 15q21.1q21.2 deletion identified through FBN1 MLPA and refined by 244K array-CGH in a female teenager with incomplete Marfan syndrome

International audience; Interstitial deletions involving the 15q21.1 band are very rare. Only 4 of these cases have been studied using molecular cytogenetic techniques in order to confirm the deletion of the whole FBN1 gene. The presence of clinical features of the Marfan syndrome (MFS) spectrum associated with mental retardation has been described in only 2/4 patients. Here we report on a 16-year-old female referred for suspicion of MFS (positive thumb and wrist sign, scoliosis, joint hyperlaxity, high-arched palate with dental crowding, dysmorphism, mitral insufficiency with dystrophic valve, striae). She had therefore 3 minor criteria according to the Ghent nosology. She also had speech …

Balance Sheet of Screening for Diabetic Retinopathy With a Mobile Non-Mydriatic Digital Camera in Burgundy, France

Purpose: To assess the economic balance-sheet of screening for diabetic retinopathy (DR) with a mobile non-mydriatic digital camera in Burgundy, France, in a public health and economic perspective.Methods: The 72 lowest medicalised areas of Burgundy were visited. Retinal images were obtained with a non-mydriatic camera. To construct an economic model, we used available data on the prevalence of diabetes in Burgundy, the efficiency of the screening, the number of screened DR, blindness probability according to DR grading, the efficiency of laser therapy, the diabetic characteristics (gender, age, income, professional status and life expectancy) and medical costs induced by our campaign.Resul…