0000000000256113

AUTHOR

G. Villa

showing 5 related works from this author

The X-ray gas scintillation spectrometer experiment on the first spacelab flight

1985

The First Spacelab mission, launched on Space ShuttleFlight STS-9 in November 1983 carried a multidisciplinary payload which was intended to demonstrate that valuable scientific results can be achieved from such short duration missions. The payload complement included a spectrometer to undertake observations of the brighter cosmic X-ray sources. The primary scientific objectives of this experiment were the study of detailed spectral features in cosmic X-ray sources and their associated temporal variations over a wide energy range from about 2 up to 30 keV. The instrument based on the gas scintillation proportional counter had an effective area of some 180 cm2 with an energy resolution of ∼9…

PhysicsScintillationCOSMIC cancer databaseSpectrometerPayloadbusiness.industryAstrophysics::High Energy Astrophysical PhenomenaAstrophysics::Instrumentation and Methods for AstrophysicsAstronomyProportional counterAstronomy and AstrophysicsCosmologyAstronomical spectroscopyOpticsSpace and Planetary ScienceScintillation counterbusinessAstrophysics and Space Science
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The optical/UV filters for the EPIC experiment

1998

EPIC, the European Photon Imaging Cameras is an experiment based on cooled CCDs on board the ESA X-ray Multi Mirrors satellite due to be launched in 1999. Since CCD's are sensitive to radiation other than X-rays, namely Optical and UV light, filters are necessary to prevent this radiation from reaching the detector sensitive area. Three types of filters were developed, to be used alternatively depending on target source. Here we report on the medium and thin filters developed by MOXTEK Inc. in Orem, Utah, while the thick ones, developed at the Max-Planck-Institut fur Extraterrestrische Physik (MPE, Germany) have been described elsewhere. The two filters, described here, have a 1600 /spl Ari…

PhysicsNuclear and High Energy PhysicsX-ray astronomyPhotonbusiness.industryDetectorRadiationParticle detectorSettore FIS/05 - Astronomia E AstrofisicaOpticsNuclear Energy and EngineeringFilter (video)CalibrationOptoelectronicsElectrical and Electronic EngineeringbusinessOptical filterIEEE Transactions on Nuclear Science
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The Gas Scintillation Proportional Counter on EXOSAT

1981

The inclusion of a gas scintillation proportional counter (GSPC) within the EXOSAT payload complement significantly improves the spectroscopic capability of the mission. This broad-band medium energy spectrometer used in conjunction with the large area proportioni counter array (ME) should provide additional spectroscopic details on strong X-ray sources at photon energies above ~ 2 keV. The novel type of detector has an energy resolution at least a factor of two better than the ME experiment over a similar bandwidth (2 – 40 keV).

PhysicsScintillationPhotonSpectrometerPhysics::Instrumentation and DetectorsDetectorProportional counterchemistry.chemical_elementComputational physicschemistryScintillation counterEmission spectrumAtomic physicsHelium
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Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: Lessons from the DAL…

2014

The aims of this study were to describe the variability in protein binding of teicoplanin in critically ill patients as well as the number of patients achieving therapeutic target concentrations. This report is part of the multinational pharmacokinetic DALI Study. Patients were sampled on a single day, with blood samples taken both at the midpoint and the end of the dosing interval. Total and unbound teicoplanin concentrations were assayed using validated chromatographic methods. The lower therapeutic range of teicoplanin was defined as total trough concentrations from 10 to 20 mg/L and the higher range as 10-30 mg/L. Thirteen critically ill patients were available for analysis. The followi…

Malevalidityvalidation proceInternational CooperationSettore MED/41 - Anestesiologiadrug protein bindingGastroenterologylaw.inventionPlasmaStaphylococcus infectionCritically ill patientsInterquartile rangelaw[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesAntibioticsantibiotic therapyPharmacology (medical)Pharmacology & PharmacyAntibiotics; Critically ill patients; Glycopeptides; Hypoalbuminaemia; ICU; Pharmacokinetics; Adult; Aged; Anti-Bacterial Agents; Chromatography; Critical Illness; Female; Humans; International Cooperation; Male; Middle Aged; Plasma; Protein Binding; Teicoplanin; Young Adult; Drug Monitoring; Microbiology (medical); Infectious Diseases; Pharmacology (medical)Antibiotics; Critically ill patients; Glycopeptides; Hypoalbuminaemia; ICU; Pharmacokinetics; Adult; Aged; Anti-Bacterial Agents; Chromatography; Critical Illness; Female; Humans; International Cooperation; Male; Middle Aged; Plasma; Protein Binding; Teicoplanin; Young Adult; Drug Monitoringclinical articleChromatographymedicine.diagnostic_testdrug dose regimencritical illneTeicoplaninHypoalbuminaemiaMedicine (all)articleGlycopeptidesclinical trialGeneral MedicineMiddle Agedtrough time concentrationdrug protein binding variabilityIntensive care unitGlycopeptides Antibiotics Critically ill patients Pharmacokinetics Hypoalbuminaemia ICU3. Good healthAnti-Bacterial Agentsantiinfective agentdrug distributionInfectious Diseases[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitologypriority journalmulticenter study (topic)Vancomycinblood samplingFemaleCritically ill patientDrug MonitoringHumanmedicine.drugProtein BindingMicrobiology (medical)Adultmedicine.medical_specialtyhigh performance liquid chromatographyarea under the curveCritical Illnessultraviolet spectroscopymid dose concentrationchemistryGlycopeptideMicrobiologyteicoplanin adultenterococcal infectionyoung adult Adultdrug clearanceYoung AdultTherapeutic indexPharmacokineticsInternal medicineAnti-Bacterial AgentmedicineHumanssteady statePharmacokineticsDosingAgedbusiness.industrydrug half lifeAntibioticrecommended drug doseAntibiotics; Critically ill patients; Glycopeptides; Hypoalbuminaemia; ICU; Pharmacokinetics; Adult; Aged; Anti-Bacterial Agents; Chromatography; Critical Illness; Female; Humans; International Cooperation; Male; Middle Aged; Plasma; Protein Binding; Teicoplanin; Young Adult; Drug Monitoring; Microbiology (medical); Infectious Diseases; Pharmacology (medical); Medicine (all)calibrationSurgerymulticenter studyTherapeutic drug monitoringdrug blood levelICU[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacologyfree plasma drug concentrationTeicoplaninbusinessmetabolism
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The European Photon Imaging Camera on XMM-Newton: The MOS Cameras

2000

The EPIC focal plane imaging spectrometers on XMM-Newton use CCDs to record the images and spectra of celestial X-ray sources focused by the three X-ray mirrors. There is one camera at the focus of each mirror; two of the cameras contain seven MOS CCDs, while the third uses twelve PN CCDs, defining a circular field of view of 30 arcmin diameter in each case. The CCDs were specially developed for EPIC, and combine high quality imaging with spectral resolution close to the Fano limit. A filter wheel carrying three kinds of X-ray transparent light blocking filter, a fully closed, and a fully open position, is fitted to each EPIC instrument. The CCDs are cooled passively and are under full clos…

PhysicsInstrumentation: detectorPhotonSpectrometerbusiness.industryDynamic rangeAstrophysics::High Energy Astrophysical PhenomenaAstrophysics (astro-ph)Astrophysics::Instrumentation and Methods for AstrophysicsFOS: Physical sciencesAstronomy and AstrophysicsField of viewAstrophysicsAstrophysicsX-rays: generalOpticsCardinal pointSpace and Planetary ScienceCalibrationSpectral resolutionbusinessFocus (optics)
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