0000000000256323
AUTHOR
Vincenzo Salamone
The Abundance of Tumor-Infiltrating CD8+ Tissue Resident Memory T Lymphocytes Correlates with Patient Survival in Glioblastoma
Glial tumors alone account for 40% of all CNS tumors and present a low survival rate. The tumor microenvironment is a critical regulator of tumor progression and therapeutic effectiveness in glioma. Growing evidence from numerous studies of human solid tumor-infiltrating CD8(+) T cells indicates that tissue-resident memory T cells (TRM) represent a substantial subpopulation of tumor-infiltrating lymphocytes (TILs). Although it is reported that some types of cancer patients with high immune infiltration tend to have better outcomes than patients with low immune infiltration, it seems this does not happen in gliomas. This study aimed to characterize TRMs cells in the glioma tumor microenviron…
Linguistic Approach to Support Human Reliability Analysis and Validation Work in Advanced Radiotherapy Technologies
An integrated methodology, that combines Hierarchical Task Analysis (HTA), Cognitive Task Analysis (CTA) and a modified Human Error Assessment and Reduction Technique (HEART), is proposed to identify safety-relevant human actions in innovative and advanced facilities. It is suggested to use in HEART the concept of linguistic expressions for proportion assessment factors. To prove its applicability, a case study is presented. The validation work has related to safety analyses of accidental events that can involve radiological over-exposure of patients during proton therapy treatments carried out by CATANA (Centro di AdroTerapia Applicazioni Nucleari Avanzate) centre, Italy. CATANA is the fir…