0000000000256477

AUTHOR

Vincenzo L'imperio

showing 3 related works from this author

Real-world digital pathology: considerations and ruminations of four young pathologists

2022

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COMPUTER SYSTEMSEDUCATIONGeneral MedicineINFORMATION TECHNOLOGY.Settore MED/08 - Anatomia PatologicaDIGITAL PATHOLOGYINFORMATION TECHNOLOGYPathology and Forensic Medicine
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In situ transcriptional profile of a germinal center plasmablastic burst hints at MYD88/CD79B mutants-enriched Diffuse Large B-cell Lymphomas

2021

AbstractThe germinal center (GC) reaction results in the selection of B-cells acquiring effector Ig secreting ability by progressing towards plasmablastic differentiation. This transition is associated with exclusion from the GC microenvironment. The aberrant expansion of plasmablastic elements within the GC fringes configures an atypical condition, the biological characteristics of which have not been defined yet. We investigated the in situ immunophenotypical and transcriptional characteristics of a non-clonal germinotropic expansion of plasmablastic elements (GEx) occurring in the tonsil of a young patient. Compared to neighboring GC and peri-follicular regions, the GEx showed a distinct…

In situTransition (genetics)Effectormedicine.medical_treatmentGerminal centerBiologymedicine.diseaseLymphomamedicine.anatomical_structureCytokineTonsilCancer researchmedicineDiffuse large B-cell lymphoma
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Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88/CD79B mutants-enriched diffuse large B-cell lymphomas

2022

The GC reaction results in the selection of B cells acquiring effector Ig secreting ability by progressing toward plasmablastic differentiation. This transition is associated with exclusion from the GC microenvironment. The aberrant expansion of plasmablastic elements within the GC fringes configures an atypical condition, the biological characteristics of which have not been defined yet. We investigated the in situ immunophenotypical and transcriptional characteristics of a nonclonal germinotropic expansion of plasmablastic elements (GEx) occurring in the tonsil of a young patient. Compared to neighboring GC and perifollicular regions, the GEx showed a distinctive signature featuring key r…

Plasma CellsImmunologyGerminal centerDiffuse large B-cell lymphomaDigital spatial profilingSettore MED/08 - Anatomia PatologicaPlasmablastDiffuse large B-cell lymphoma; Digital spatial profiling; Germinal center; Plasmablastdigital spatial profiling; germinal center; plasmablast; diffuse large b-cell lymphomaMyeloid Differentiation Factor 88Tumor MicroenvironmentHumansSettore MED/05 - Patologia ClinicaImmunology and AllergyLymphoma Large B-Cell DiffuseTranscriptomeCD79 AntigensDiffuse large B-cell lymphoma ⋅ Digital spatial profiling ⋅ Germinal center ⋅ Plasmablast
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