0000000000261609

AUTHOR

Alessandro Inserra

showing 5 related works from this author

Salvage treatment for children with relapsed/refractory germ cell tumors: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experienc…

2020

Background Malignant germ cell tumors (GCTs) are a heterogeneous group of rare neoplasms in children. Optimal outcome is achieved with multimodal therapies for patients with both localized and advanced disease, especially after the introduction of platinum-based chemotherapy regimens. In this respect, data on salvage treatment for children with relapsed or platinum-refractory disease are still limited. Methods Retrospective analysis of data regarding patients affected by malignant GCTs with platinum-refractory or relapsed disease after first-line treatment according to AIEOP TCGM 2004 protocol was conducted. Results Twenty-one patients, 15 females and 6 males, were considered for the analys…

OncologyMelphalanMalemedicine.medical_treatmentDrug ResistanceSalvage therapyrelapsed tumorsDeoxycytidineCarboplatinchemistry.chemical_compound0302 clinical medicineNeoplasmsAntineoplastic Combined Chemotherapy Protocolsgerm cell tumorsChildEtoposideIfosfamideRemission InductionHematologyNeoplasms Germ Cell and EmbryonalPrognosisgerm cell tumors; high-dose chemotherapy; pediatric tumors; refractory tumors; relapsed tumors; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child Preschool; Cisplatin; Deoxycytidine; Drug Resistance Neoplasm; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Infant; Male; Neoplasm Recurrence Local; Neoplasms Germ Cell and Embryonal; Oxaliplatin; Paclitaxel; Prognosis; Remission Induction; Retrospective Studies; Survival Rate; Salvage Therapypediatric tumorsOxaliplatinSurvival RateLocalOncology030220 oncology & carcinogenesisChild PreschoolFemalerefractory tumorsmedicine.drugmedicine.medical_specialtyAdolescentPaclitaxelThioTEPA03 medical and health sciencesInternal medicinemedicineHumansIfosfamidePreschoolSurvival rateRetrospective StudiesSalvage TherapyChemotherapybusiness.industryInfantmedicine.diseaseGemcitabineCarboplatinNeoplasm RecurrencechemistryDrug Resistance NeoplasmPediatrics Perinatology and Child HealthSettore MED/20NeoplasmGerm Cell and EmbryonalGerm cell tumorsCisplatinNeoplasm Recurrence Localbusinesshigh-dose chemotherapy030215 immunologyFollow-Up StudiesPediatric bloodcancerREFERENCES
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Bedside surgery in the newborn infants: Survey of the Italian society of pediatric surgery

2020

Abstract Introduction This is the report of the first official survey from the Italian Society of Pediatric Surgery (ISPS) to appraise the distribution and organization of bedside surgery in the neonatal intensive care units (NICU) in Italy. Methods A questionnaire requesting general data, staff data and workload data of the centers was developed and sent by means of an online cloud-based software instrument to all Italian pediatric surgery Units. Results The survey was answered by 34 (65%) out of 52 centers. NICU bedside surgery is reported in 81.8% of the pediatric surgery centers. A lower prevalence of bedside surgical practice in the NICU was reported for Southern Italy and the islands …

Neonatal intensive care unitmedicine.medical_treatmentPractice PatternsReviewBedside surgeryNeonatal intensive care unit Bedside surgery Operative room Intrahospital transport Critically ill neonates0302 clinical medicineInformed consentNeonatalSurveys and QuestionnairesPediatric surgeryPractice Patterns Physicians'Societies MedicalBedside surgery; Critically ill neonates; Intrahospital transport; Neonatal intensive care unit; Operative roomlcsh:RJ1-570Operative roomOperativeCritically ill neonatesIntensive Care UnitsPneumothoraxItaly030220 oncology & carcinogenesisSurgical Procedures OperativeCentral venous catheterInfant Prematuremedicine.medical_specialtyPerforation (oil well)Critically ill neonate03 medical and health sciencesNeonatal intensive care unitMedical030225 pediatricsIntensive careIntensive Care Units NeonatalmedicineHumansPrematureContraindicationPhysicians'Surgical Proceduresbusiness.industryBedside surgery Critically ill neonates Intrahospital transport Neonatal intensive care unit Operative room Humans; Infant Newborn Infant Premature Italy Practice Patterns Physicians' Societies Medical Surveys and Questionnaires Intensive Care Units Neonatal Surgical Procedures OperativeInfant NewbornInfantlcsh:PediatricsIntrahospital transportNewbornmedicine.diseaseSurgeryOperative room.Settore MED/20Societiesbusiness
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Malignant ovarian germ cell tumors in pediatric patients: The AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) study.

2017

Objective Malignant ovarian germ cell tumors (MOGCT) carry an excellent prognosis, and the treatment aims to achieve results with the least possible treatment-related morbidity. The aim of this study was to assess the outcomes of pediatric patients with MOGCT. Methods Patients were treated according to their stage: surgery and surveillance for stage I; a modified bleomycin–etoposide–cisplatin (BEP) regimen for stages II (three cycles), III, and IV (three cycles) with surgery on residual disease. Results Seventy-seven patients were enrolled (median age 11.8 years), 26 with dysgerminoma (Dysg), 13 with immature teratoma and elevated serum alpha-fetoprotein levels (IT + AFP), and 38 with nondy…

0301 basic medicineMalechildhood; germ cell tumors; ovarianGastroenterology0302 clinical medicineAntineoplastic Combined Chemotherapy ProtocolsMedicineProspective StudiesStage (cooking)germ cell tumorsProspective cohort studyChildEtoposideOvarian NeoplasmsHematologychildhood germ cell tumors ovarianNeoplasms Germ Cell and EmbryonalPrognosisCombined Modality TherapySurvival RateOncology030220 oncology & carcinogenesisChild PreschoolFemalemedicine.medical_specialtyAdolescentOvariectomy03 medical and health sciencesBleomycinInternal medicineDysgerminomaovarianHumansSurvival ratechildhoodNeoplasm Stagingbusiness.industrySettore MED/20 - Chirurgia Pediatrica E InfantileInfantmedicine.diseaseSurgeryRegimen030104 developmental biologyPediatrics Perinatology and Child HealthSettore MED/20Immature teratomaGerm cell tumorsCisplatinbusinessProgressive diseaseFollow-Up StudiesPediatric bloodcancer
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Teratoma with a malignant somatic component in pediatric patients: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience

2010

Background Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse. Procedure The Associazione Italiana Ematologia Oncologia Pediatrica identified 14 cases of TMSC. Clinical files and pathology specimens were reviewed. Results The series (9 female, 5 male) showed the following disease: testis (2), sacrococcygeal (3), ovary (3), retroperitoneum (3), mediastinum (2), and foot soft tissue (1). Distribution of the somatic component was: carcinoma (4), pancreatic neuroendocrine tumor (1), neuroblastoma (3), rhabdomyosarcoma (3), rhabdomyosarcoma plus liposarcoma, chondrosarcoma, neurogenic sarcoma (1), chondrosar…

medicine.medical_specialtyPathologybusiness.industryMalignant peripheral nerve sheath tumorHematologyLiposarcomamedicine.diseaseOncologyPediatrics Perinatology and Child HealthmedicineCarcinomaRadiologyGerm cell tumorsTeratomaSarcomaChondrosarcomaRhabdomyosarcomabusinessPediatric Blood & Cancer
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Fibrosarcoma in pediatric patients: Results of the Italian Cooperative Group Studies (1979-1995)

2001

Background and Objectives Fibrosarcoma is a rare soft tissue sarcoma (STS) that has two peaks of incidence in pediatric patients: one in infants and young childern (infantile fibrosarcoma), another in older children (“adult type” fibrosarcoma). The purpose of this study was to describe the clinical features and the treatment results in patients affected by fibrosarcoma enrolled in two consecutive studies run by the STS-Italian Cooperative Group (ICG) between 1979 and 1995. Patients and Methods Twenty-five evaluable patients were grouped according the intergroup rhabdomyosarcoma staging (IRS) system: 12 Gr I, 5 Gr II, 8 Gr III. The cut-off point between the two forms was considered the age o…

Malemedicine.medical_specialtyinfantile fibrosarcomaAdolescentmedicine.medical_treatmentSoft Tissue NeoplasmsSettore MED/38 - Pediatria Generale E SpecialisticamedicineHumansFibrosarcomaRhabdomyosarcomaChildSurvival analysisfibrosarcoma; infantile fibrosarcoma; soft tissue sarcomabusiness.industrySoft tissue sarcomaSettore MED/20 - Chirurgia Pediatrica E InfantileAge FactorsInfantRadiotherapy DosageSarcomaGeneral Medicinemedicine.diseaseCombined Modality TherapySurvival AnalysisSurgeryRadiation therapyTreatment OutcomeOncologyChild Preschoolsoft tissue sarcomaSurgeryFemalefibrosarcomaSarcomaInfantile FibrosarcomabusinessProgressive disease
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