0000000000262579

AUTHOR

J. De Boer

Evidence for a two-phonon octupole vibrational state in208Pb

Collective properties of206,208Pb have been investigated with gamma-ray spectroscopy using nuclear and electromagnetic excitation by208Pb projectiles. From the measurement of particle-particle-γ and particle-particle-γ γ coincidences a new energy level in208Pb at 5.683 MeV was observed and the data suggest an interpretation as a 2-phonon octupole vibrational state with spin 4+ or 6+. For this state one finds the same dynamical deformation parameterβ3 as for the first-excited collective 3− state. The results are compared to predictions of models which consider, in particular, the aspects of the quadrupole interaction and the interaction of the 2-particle pairing vibration with the 2-phonon o…

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Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial

BACKGROUND: Systemic relapses remain a major problem in locally advanced rectal cancer. Using short-course radiotherapy followed by chemotherapy and delayed surgery, the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation (RAPIDO) trial aimed to reduce distant metastases without compromising locoregional control. METHODS: In this multicentre, open-label, randomised, controlled, phase 3 trial, participants were recruited from 54 centres in the Netherlands, Sweden, Spain, Slovenia, Denmark, Norway, and the USA. Patients were eligible if they were aged 18 years or older, with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, had a biopsy-prove…

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