0000000000266233

AUTHOR

Stefan Löffler

showing 4 related works from this author

Synthesis and Oxidant Properties of Phase 1 Benzepine N-Oxides of Common Antipsychotic Drugs

2013

There is increasing evidence that cell constituents are oxidized by widely used antipsychotic drugs but until now the underlying chemistry has remained unclear. It is well known that such drugs readily undergo N-oxidation as a first key metabolic step. To gain insight into the problem, the tertiary phase 1 N-oxides of clozapine, olanzapine, quetiapine, and zotepine were synthesized, together with the N,S-dioxides of quetiapine and zotepine. These N-oxides were then subjected to well-established chemical transformations to test their oxidant properties in group VIII transition-metal­-catalyzed reactions. In the osmium tetroxide catalyzed dihydroxylation of styrene or cinnamyl alcohol and in …

OlanzapineCinnamyl alcoholChemistryOrganic ChemistryRedoxCatalysischemistry.chemical_compoundTetrapropylammonium perruthenateZotepineDihydroxylationmedicineOrganic chemistryQuetiapineClozapinemedicine.drugSynthesis
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CCDC 907670: Experimental Crystal Structure Determination

2013

Related Article: Jochen Körber, Stefan Löffler, Dieter Schollmeyer, Udo Nubbemeyer|2013|Synthesis|45|2875|doi:10.1055/s-0033-1338519

(2-((8-Chlorodibenzo[bf]thiepin-10-yl)oxy)ethyl)dimethylamine oxide dihydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 907672: Experimental Crystal Structure Determination

2013

Related Article: Jochen Körber, Stefan Löffler, Dieter Schollmeyer, Udo Nubbemeyer|2013|Synthesis|45|2875|doi:10.1055/s-0033-1338519

Space GroupCrystallography2-(2-(4-(Dibenzo[bf][14]thiazepin-11-yl)-1-oxidopiperazin-1-yl)ethoxy)ethanol methanol solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 907671: Experimental Crystal Structure Determination

2013

Related Article: Jochen Körber, Stefan Löffler, Dieter Schollmeyer, Udo Nubbemeyer|2013|Synthesis|45|2875|doi:10.1055/s-0033-1338519

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(2-((8-Chloro-5-oxidodibenzo[bf]thiepin-10-yl)oxy)ethyl)dimethylamine oxide dihydrateExperimental 3D Coordinates
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