0000000000266233
AUTHOR
Stefan Löffler
Synthesis and Oxidant Properties of Phase 1 Benzepine N-Oxides of Common Antipsychotic Drugs
There is increasing evidence that cell constituents are oxidized by widely used antipsychotic drugs but until now the underlying chemistry has remained unclear. It is well known that such drugs readily undergo N-oxidation as a first key metabolic step. To gain insight into the problem, the tertiary phase 1 N-oxides of clozapine, olanzapine, quetiapine, and zotepine were synthesized, together with the N,S-dioxides of quetiapine and zotepine. These N-oxides were then subjected to well-established chemical transformations to test their oxidant properties in group VIII transition-metal-catalyzed reactions. In the osmium tetroxide catalyzed dihydroxylation of styrene or cinnamyl alcohol and in …
CCDC 907670: Experimental Crystal Structure Determination
Related Article: Jochen Körber, Stefan Löffler, Dieter Schollmeyer, Udo Nubbemeyer|2013|Synthesis|45|2875|doi:10.1055/s-0033-1338519
CCDC 907672: Experimental Crystal Structure Determination
Related Article: Jochen Körber, Stefan Löffler, Dieter Schollmeyer, Udo Nubbemeyer|2013|Synthesis|45|2875|doi:10.1055/s-0033-1338519
CCDC 907671: Experimental Crystal Structure Determination
Related Article: Jochen Körber, Stefan Löffler, Dieter Schollmeyer, Udo Nubbemeyer|2013|Synthesis|45|2875|doi:10.1055/s-0033-1338519