Author: P. Tolosa

0000000000266310

AUTHOR

P. Tolosa

showing 2 related works from this author

NRF2 activation via PI3K/AKT/mTOR/RPS6 causes resistance to anti-HER2 agents among HER2 amplified gastric cancer

2018

0301 basic medicinebusiness.industryCancerHematologymedicine.diseaseNrf2 activation03 medical and health sciences030104 developmental biology0302 clinical medicineOncologyCancer researchMedicineAnti her2businessProtein kinase B030217 neurology & neurosurgeryPI3K/AKT/mTOR pathwayAnnals of Oncology

researchProduct

NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug Resistance in HER2-Amplified Gastric Cancer

2019

Abstract Purpose: Despite the clinical advantage of the combination of trastuzumab and platinum-based chemotherapy in HER2-amplified tumors, resistance will eventually develop. The identification of molecular mechanisms related to primary and acquired resistance is needed. Experimental Design: We generated lapatinib- and trastuzumab-resistant clones deriving from two different HER2-amplified gastric cancer cell lines. Molecular changes such as protein expression and gene-expression profile were evaluated to detect alterations that could be related to resistance. Functional studies in vitro were corroborated in vivo. The translational relevance of our findings was verified in a patient cohor…

0301 basic medicineCancer ResearchGene knockdownbusiness.industryCancerDrug resistancerespiratory systemmedicine.diseaseLapatinib03 medical and health sciences030104 developmental biology0302 clinical medicineOncologyTrastuzumabIn vivo030220 oncology & carcinogenesismedicineCancer researchskin and connective tissue diseasesbusinessProtein kinase BPI3K/AKT/mTOR pathwaymedicine.drugClinical Cancer Research

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