Anti-tumor activity of two binuclear gold(I) complexes with bridging dithiolate ligands

Abstract Two new binuclear complexes of gold with bridging dithiolate ligands were synthesized and characterized: (o3PAu)2(μ-DTE) and (Et3PAu)2(μ-DMTA); H2DTE=dithioerylthritol and H2DMTA=2,5-dimer- capto-1-thia-3,4-diazole. These compounds and three gold compounds with antiarthritic activity (gold sodium thiomalate, gold thioglucose and Et3PAuCl) were tested for antitumor activity using the Ehrlich- Ascites tumor cell in mice. Only (o3PAu)e(μ-DTE) showed significant activity.