0000000000267030

AUTHOR

Isabelle Iacono

showing 2 related works from this author

Influence of Neuroblastoma Stage on Serum-Based Detection of MYCN Amplification

2009

BACKGROUND: MYCN oncogene amplification has been defined as the most important prognostic factor for neuroblastoma (NB), the most common solid extracranial neoplasm in children. High copy numbers are strongly associated with rapid tumor progression and poor outcome, independently of tumor stage or patient age, and this has become an important factor in treatment stratification. PROCEDURE: By real-time quantitative PCR analysis, we evaluated the clinical relevance of circulating MYCN DNA of 267 patients with locoregional or metastatic NB in children less than 18 months of age. RESULTS: For patients in this age group with INSS stage 4 or 4S NB and stage 3 patients, serum-based determination o…

Neuroblastoma stageGenes mycArticleNeuroblastomaPatient ageNeuroblastomaGene duplicationmedicineNeoplasmHumansChildneoplasmsRetrospective StudiesNeoplasm Stagingbusiness.industryGene AmplificationChild; DNA Neoplasm/blood; Gene Amplification; Genes myc; Humans; Neoplasm Staging; Neuroblastoma/genetics; Neuroblastoma/pathology; Retrospective StudiesRetrospective cohort studyHematologyDNA Neoplasmmedicine.diseaseOncologyTumor progressionPediatrics Perinatology and Child HealthMycn amplificationCancer researchbusiness
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Circulating MYCN DNA Predicts MYCN-Amplification in Neuroblastoma

2005

Oncogene ProteinsN-Myc Proto-Oncogene ProteinCancer Researchbusiness.industryGene AmplificationNuclear ProteinsDNA Neoplasmmedicine.diseaseDiagnosis DifferentialNeuroblastomachemistry.chemical_compoundOncologychemistryPredictive Value of TestsNeuroblastomaMycn amplificationCancer researchmedicineHumansbusinessDNAJournal of Clinical Oncology
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