0000000000267398

AUTHOR

S Di Franco

showing 2 related works from this author

Recreational and small-scale fisheries may pose a threat to vulnerable species in coastal and offshore waters of the western Mediterranean

2019

10 pages, 3 figures, supplementary material https://doi.org/10.1093/icesjms/fsz071

0106 biological sciencesMediterranean climateSmall-scale fishers (SSF)Target and by-catch[SDE.MCG]Environmental Sciences/Global Changesrecreational and small-scale fishingAquatic ScienceOceanography010603 evolutionary biology01 natural sciencesAUTfisheries management marine protected areas recreational fisheries (RF) small-scale fisheries (SSF) target and bycatch threatened speciesMarine protected areasVulnerable species14. Life underwaterRecreationfishing pressureEcology Evolution Behavior and Systematicsfishing impacts on vulnerable speciesEcology010604 marine biology & hydrobiologyExtinction[SDE.ES]Environmental Sciences/Environmental and SocietyManagementFisheryGeographyScale (social sciences)[SDE]Environmental SciencesCoastal and offshore fisheriesMarine protected areaSubmarine pipeline[SDE.BE]Environmental Sciences/Biodiversity and EcologyFishing methodswestern mediterranean
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Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification

2016

Cancer is associated with strong changes in lipid metabolism. For instance, normal cells take up fatty acids (FAs) from the circulation, while tumour cells generate their own and become dependent on de novo FA synthesis, which could provide a vulnerability to target tumour cells. Betulinic acid (BetA) is a natural compound that selectively kills tumour cells through an ill-defined mechanism that is independent of BAX and BAK, but depends on mitochondrial permeability transition-pore opening. Here we unravel this pathway and show that BetA inhibits the activity of steroyl-CoA-desaturase (SCD-1). This enzyme is overexpressed in tumour cells and critically important for cells that utilize de n…

0301 basic medicineCancer ResearchProgrammed cell deathCardiolipinsMitochondrionCell Line03 medical and health scienceschemistry.chemical_compoundSDG 3 - Good Health and Well-beingBetulinic acidGeneticsCardiolipinHumansBetulinic AcidCytotoxicityMolecular BiologyCell DeathbiologyCytochrome cFatty AcidsCytochromes cLipid metabolismAntineoplastic Agents PhytogenicTriterpenesMitochondriaCell biology030104 developmental biologyBiochemistrychemistryCancer cellbiology.protein/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingPentacyclic TriterpenesStearoyl-CoA Desaturase
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