0000000000273594
AUTHOR
W. Hevers
Ionic currents ofdrosophila embryonic neurons derived from selectively cultured CNS midline precursors
In order to investigate the electrogenesis of defined cell populations, we applied an in vitro system that allows the selective culturing of individual Drosophila CNS precursors under different conditions. CNS midline (ML) precursors prepared from gastrula stage embryos gave rise to progeny cells with neuronal and glial morphology that expressed specific markers. Using whole-cell patch-clamp recordings, a detailed description of ionic currents present in this defined cell population is provided. Most ionic currents of cultured ML neurons were similar to other cultured Drosophila neurons, even though their embryonic origin is different. They displayed at least two voltage-gated potassium cur…
Electrophysiological evidence for an inverse benzodiazepine receptor agonist in panic disorder.
Abstract Inverse agonists of the GABA A receptor clearly decrease the amplitudes of the spontaneous EEG in the P-frequency range. Therefore, we tested the hypothesis that panic patients exhibit a reduction of the EEGs spectral power in the P-frequency band. Ten unmedicated patients with panic disorder and agoraphobia according to DSM-III-R criteria and 10 matched controls were investigated under baseline conditions, after hyperventilation and 30 min after hyperventilation. EEG recordings from the position P z and C z were performed under eyes closed conditions. At baseline conditions the patients suffering from panic disorder depicted a reduced P-power reaching statistically significance fo…