0000000000278227

AUTHOR

Eliana Martino

showing 3 related works from this author

Obesity and the metabolic syndrome in a student cohort from Southern Italy

2009

Abstract Background and aim Cardiovascular (CV) risk factors present in childhood predict future CV events. Few data regarding the metabolic syndrome (MS) prevalence are available in adolescents from Mediterranean areas where obesity is becoming a social emergency. This study presents data of MS prevalence in a student cohort from southern Italy. Methods and results 1629 students between 7 and 14 years of age underwent anthropometric measurements and a blood sample was obtained to assess biochemical parameters. MS risk factors were calculated based on age and gender adjusted percentiles of parameter distributions. MS prevalence rate was 0.022 using paediatric, age-adjusted criteria; the rat…

Malecardiovascular risk factorsmedicine.medical_specialtypaediatricAdolescentEndocrinology Diabetes and MetabolismMedicine (miscellaneous)Blood sugarpaediatric; metabolic syndrome; factor analysis; cardiovascular risk factorsfactor analysisType 2 diabetesCardiovascular risk factormetabolic syndromeCohort StudiesRisk FactorsInternal medicinePrevalenceHumansMedicineObesityChildStudentsNutrition and Dieteticsbusiness.industryType 2 Diabetes MellitusOverweightmedicine.diseaseObesityEndocrinologyItalyCardiovascular DiseasesCohortFemaleMetabolic syndromeCardiology and Cardiovascular MedicinebusinessBody mass indexCohort study
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Plasma non-cholesterol sterols: a useful diagnostic tool in pediatric hypercholesterolemia.

2010

Current guidelines strongly recommend the identification of genetic forms of hypercholesterolemia (HC) during childhood. The usefulness of non–cholesterol sterols (NCS) in the diagnosis of genetic HC has not been fully explored. Plasma NCS were measured by gas chromatography/mass spectrometry (GC/MS) in 113 children with hypercholesterolemia affected by: autosomal dominant hypercholesterolemia (ADH), familial combined hyperlipidemia (FCHL), polygenic hypercholesterolemia (PHC), and in 79 controls to evaluate: i) plasma NCS profile in different genetic HC and ii) the usefulness of NCS for the diagnosis of HC beyond current clinical criteria. ADH was characterized by raised lathosterol/total …

Cholesterol synthesisMalemedicine.medical_specialtyMultifactorial InheritanceSettore MED/09 - Medicina InternaAdolescentHyperlipidemia Familial CombinedLathosterolIncreased Cholesterol Synthesisbehavioral disciplines and activitiesGas Chromatography-Mass SpectrometryHyperlipoproteinemia Type IIchemistry.chemical_compoundPredictive Value of TestsInternal medicineBlood plasmaMedicineHumansGenetic Predisposition to DiseaseChildhypercholesterolemiabusiness.industryCholesterolDiscriminant AnalysisPhytosterolsSitosterolsSterolFamilial combined hyperlipidemiaSterolsEndocrinologypediatricCholesterolchemistryItalyCase-Control StudiesPediatrics Perinatology and Child Healthlipids (amino acids peptides and proteins)FemalebusinessBiomarkersLipoproteinPediatric research
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Down regulation of CD11b and CD18 expression in children with hypercholesterolemia: A preliminary report.

2009

BACKGROUND AND AIM: Cell adhesion molecules play an important role in the development of atherosclerosis mediating the attachment of monocytes to the endothelium. The aim of our study was to assess the cell surface expression of CD11b/CD18 integrin on the phagocytes of children affected by hypercholesterolemia. METHODS AND RESULTS: Twenty-six children with hypercholesterolemia (15 males, mean age 8.3, range 2-18) with a family history of early cardiovascular disease, as well as 26 children with normocholesterolemia matched for gender and age (15 males, mean age 8.3) were studied. Cell surface expression of CD11b/CD18 on peripheral blood mononuclear cells (PBMC) were analyzed by flow cytomet…

MaleSettore MED/09 - Medicina InternaAdolescentEndotheliumEndocrinology Diabetes and MetabolismDown-RegulationMedicine (miscellaneous)Pilot ProjectsCD18Context (language use)Peripheral blood mononuclear cellFlow cytometrychildrencd11b/cd18HumansMedicineFamily historyChildCD18PhagocytesCD11b AntigenNutrition and Dieteticsatherosclerosis; cd11b; cd11b/cd18; cd18; children; hypercholesterolemiahypercholesterolemiamedicine.diagnostic_testbiologybusiness.industryCell adhesion moleculeCD11bLipidsCross-Sectional Studiesmedicine.anatomical_structureIntegrin alpha MCD18 AntigensCase-Control StudiesChild PreschoolImmunologybiology.proteinFemaleatherosclerosisCardiology and Cardiovascular Medicinebusiness
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