0000000000280406
AUTHOR
Frédéric Rabiet
Synthesis of Macropolycyclic Ligands Based on Tetraazacycloalkanes
A versatile synthesis of spherical macrobicyclic and cylindrical macrotricyclic ligands is described using 1,4,8,11-tetraazacyclotetradecane (cyclam), 1,4,7,10-tetraazacyclododecane (cyclen), or dioxo macrocycles as precursors. Macrobicycles have been obtained by allowing cyclam, cyclen, or 5,12-dioxocyclam (1,4,8,11-tetraazacyclotetradecane-5,12-dione) to react with a bis-electrophilic spacer under high dilution conditions. A surprising selectivity has been observed for 2,6-dioxocyclen (1,4,7,10-tetraazacyclododecane-2,6-dione), which yields only macrotricycles under the same reaction conditions. Molecular modelling studies have been carried out to investigate the selectivity of the reacti…
ChemInform Abstract: A New Synthesis of Macrotricyclic Ligand Based on 1,4,8,11- Tetraazacyclotetradecane.
Abstract A convenient five-step synthesis of a cylindrical macrotricyclic ligand containing two cyclam units linked together by two m-xylyl bridges is reported starting from “trans” dioxocyclam as diprotected macrocycle.
A New Synthesis of Macrotricyclic Ligand Based on 1,4,8,11-Tetraazacyclotetradecane
Abstract A convenient five-step synthesis of a cylindrical macrotricyclic ligand containing two cyclam units linked together by two m-xylyl bridges is reported starting from “trans” dioxocyclam as diprotected macrocycle.