NEW BIODEGRADABLE HYDROGELS DESIGNED FOR COLONIC DRUG DELIVERY: IN VITRO RELEASE OF THE PEPTIDES GLUTATHIONE AND OXYTOCIN

New Biodegradable Hydrogels Based on Inulin and α,β-Polyaspartylhydrazide Designed for Colonic Drug Delivery: In Vitro Release of Glutathione and Oxytocin.

Succinic derivatives of inulin (INU-SA) with two different degrees of derivatization (20% and 30%, mol/mol) were cross-linked with α,β-polyaspartylhydrazide (PAHy) to obtain INUPAHy hydrogels. Cross-linking was performed using N-ethyl-N-(3-dimethylaminopropyl)-carbodiimide hydrochloride (EDC) and N-hydroxysulfosuccinimide (NHSS) as coupling agents and by varying the reaction time (4 h, 8 h and 24 h). All samples prepared were characterized by FT-IR analysis and swelling measurements in different media. In vitro assays, performed in the presence of inulinase, demonstrated the degradability of the prepared hydrogels. Cell compatibility was evaluated using Caco-2 cells through both direct and …

Triphenylphosphane Pt(II) complexes containing biologically active natural polyphenols: Synthesis, crystal structure, molecular modeling and cytotoxic studies

Platinum complexes bearing phosphane ligands in cis configuration with deprotonated flavonoids (3-hydroxyflavone, quercetin) and deprotonated ethyl gallate were synthesized starting from cis-[PtCl2(PPh3)(2)]. In all cases, O,O' chelate structures were obtained. While quercetin and ethyl gallate complexes are quite stable in solution, the 3-hydroxyflavonate complex undergoes a slow aerobic photodegradation in solution with formation of salicylic and benzoic acids. The X-ray diffraction structures of quercetin and ethyl gallate complexes are reported. Cell cycle studies (in the dark) of the complexes in two human cell lines revealed that the cytotoxic activity of the complex bearing 3-hydroxy…

CCDC 1430059: Experimental Crystal Structure Determination

Related Article: Maria Michela Dell'Anna, Valentina Censi, Benedetta Carrozzini, Rocco Caliandro, Nunzio Denora, Massimo Franco, Daniele Veclani, Andrea Melchior, Marilena Tolazzi, Piero Mastrorilli|2016|J.Inorg.Biochem.|163|346|doi:10.1016/j.jinorgbio.2016.08.006

CCDC 1430058: Experimental Crystal Structure Determination

Related Article: Maria Michela Dell'Anna, Valentina Censi, Benedetta Carrozzini, Rocco Caliandro, Nunzio Denora, Massimo Franco, Daniele Veclani, Andrea Melchior, Marilena Tolazzi, Piero Mastrorilli|2016|J.Inorg.Biochem.|163|346|doi:10.1016/j.jinorgbio.2016.08.006