0000000000286024

AUTHOR

A. Bauer

showing 5 related works from this author

Non-steroidal anti-inflammatory agents. Part 23. Synthesis and Pharmacological Activity of Enaminones which inhibit both bovine cyclooxygenase and 5-…

1998

The synthesis and stereochemical characteristics of pyrrolidino-, isoquinolino- and indolo-enaminones 2–11 are reported. The inhibition of cyclooxygenase was determined in a bovine thrombocyte intact cell assay and that of 5-lipoxygenase using intact bovine polymorphonuclear leucocytes. Except compound 2c′ which is a well-balanced dual inhibitor of both enzymes, all other enaminone derivatives are weak inhibitors of both cyclooxygenase and 5-lipoxygenase. Structure-activity relationships of the enaminones in relation to known anti-inflammatory drugs are discussed.

chemistry.chemical_classificationEnzymebiologychemistryNon steroidal anti inflammatoryArachidonate 5-lipoxygenasebiology.proteinDual inhibitorPlateletBiological activityIntact cellCyclooxygenasePharmacologyJournal f�r Praktische Chemie/Chemiker-Zeitung
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The Belle II vertex detector integration

2019

Belle II DEPFET, PXD, and SVD Collaborations: et al.

Nuclear and High Energy PhysicsPhysics::Instrumentation and DetectorsSilicon sensorPhase (waves)Computer Science::Computational Geometry7. Clean energy01 natural scienceslaw.inventionNuclear physicsBelle II; Data acquisition; Pixel detector; Silicon sensor; Strip detector; Vertex detector; Nuclear and High Energy Physics; InstrumentationData acquisitionlaw0103 physical sciencesVertex detectorBelle IIStrip detectorColliderInstrumentationNuclear and High Energy PhysicPhysicsInterconnectionPixel010308 nuclear & particles physicsDetectorBelle II; data acquisition; pixel detector; silicon sensor; strip detector; vertex detectorData acquisitionPixel detectorUpgradeHigh Energy Physics::ExperimentFocus (optics)Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
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ChemInform Abstract: Pyrrolidino Enaminones Structurally Related to Gyrase Inhibitors: Synthesis, Cyclization and Pharmacological Activity.

2010

ChemistryStereochemistryBiological activityGeneral MedicineDNA gyraseCombinatorial chemistryPyrrole derivativesChemInform
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ChemInform Abstract: Non-Steroidal Antiinflammatory Agents. Part 23. Synthesis and Pharmacological Activity of Enaminones which Inhibit Both Bovine C…

2010

biologyChemistryArachidonate 5-lipoxygenasebiology.proteinBiological activityGeneral MedicineCyclooxygenasePharmacologyPyrrole derivativesNon steroidalChemInform
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ChemInform Abstract: Non-Steroidal Antiinflammatory Agents. Part 22. Pyrrolidino-enaminones with an Acetic Acid Function at C-3: Synthesis and Inhibi…

2010

chemistry.chemical_classificationbiologyStereochemistryGeneral MedicineNon steroidalPyrrole derivativesAcetic acidchemistry.chemical_compoundEnzymechemistryArachidonate 5-lipoxygenasebiology.proteinOrganic chemistryCyclooxygenaseFunction (biology)ChemInform
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