Non-steroidal anti-inflammatory agents. Part 23. Synthesis and Pharmacological Activity of Enaminones which inhibit both bovine cyclooxygenase and 5-lipoxygenase

The synthesis and stereochemical characteristics of pyrrolidino-, isoquinolino- and indolo-enaminones 2–11 are reported. The inhibition of cyclooxygenase was determined in a bovine thrombocyte intact cell assay and that of 5-lipoxygenase using intact bovine polymorphonuclear leucocytes. Except compound 2c′ which is a well-balanced dual inhibitor of both enzymes, all other enaminone derivatives are weak inhibitors of both cyclooxygenase and 5-lipoxygenase. Structure-activity relationships of the enaminones in relation to known anti-inflammatory drugs are discussed.

The Belle II vertex detector integration

Belle II DEPFET, PXD, and SVD Collaborations: et al.

ChemInform Abstract: Pyrrolidino Enaminones Structurally Related to Gyrase Inhibitors: Synthesis, Cyclization and Pharmacological Activity.

ChemInform Abstract: Non-Steroidal Antiinflammatory Agents. Part 23. Synthesis and Pharmacological Activity of Enaminones which Inhibit Both Bovine Cyclooxygenase and 5-Lipoxygenase.

ChemInform Abstract: Non-Steroidal Antiinflammatory Agents. Part 22. Pyrrolidino-enaminones with an Acetic Acid Function at C-3: Synthesis and Inhibition of the Enzymes Cyclooxygenase and 5-Lipoxygenase.