0000000000288022
AUTHOR
F. Sanz
An Efficient and Simple Entry to N-Substituted beta-Enamino Acid Derivatives from 2-Alkyl-2-oxazolines and 2-Alkyl-2-thiazolines.
Reaction of azaenolates of 2-alkyl-oxa(thia)zolines 6 with imidoyl chlorides 7 as electrophiles to furnish masked N-substituted beta-enamino acid derivatives 1-2 in 70-90% yield is described. Alternative routes are discussed. Compounds 1-2 generally appear in one tautomeric form, imino or enamino, depending on the nature of the imidoyl chloride. The configuration of the enamino moiety (Z) and the conformation (s-cis) of compounds 1-2 obtained were established by an NMR study and unequivocally set by nuclear Overhauser effect difference experiments. An X-ray structure of compound 1e is also reported, showing a strong intramolecular NH.N hydrogen bond. Ab initio calculations (HF/3-21G and HF/…
Upregulated MicroRNAs 342 and 15a Mediate Host-Pathogen Interaction in Pneumococcal Community-Acquired Pneumonia
Effect of antiviral treatment in older patients hospitalized with confirmed influenza
Abstract Seasonal influenza causes significant morbidity and mortality in people aged ≥65 years. Antiviral treatment can reduce complications and disease severity. The objective of this study was to investigate the effect of antiviral treatment in patients aged ≥65 years hospitalized with confirmed influenza in preventing intensive care unit (ICU) admission or death. A retrospective cohort study was carried out in 20 hospitals from seven Spanish regions during 2013–2015 in patients aged ≥65 years. Hospitalized cases of laboratory-confirmed influenza were selected. To assess the association between antiviral treatment and ICU admission or death, the adjusted odds ratios (aOR) and their 95% c…
CCDC 210648: Experimental Crystal Structure Determination
Related Article: J.Perez, L.Garcia, E.Perez, J.L.Serrano, J.F.Martinez, G.Sanchez, G.Lopez, A.Espinosa, M.Liu, F.Sanz|2003|New J.Chem.|27|1490|doi:10.1039/b302653a
CCDC 150110: Experimental Crystal Structure Determination
Related Article: L.Gutierrez, G.Alzuet, J.Borras, M.Liu-Gonzalez, F.Sanz, A.Castineiras|2001|Polyhedron|20|703|doi:10.1016/S0277-5387(01)00717-3
CCDC 245524: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, F.Sanz, J.Borras, M.Gonzalez-Alvarez, G.Alzuet|2005|J.Inorg.Biochem.|99|1441|doi:10.1016/j.jinorgbio.2005.04.001
CCDC 164813: Experimental Crystal Structure Determination
Related Article: M.Gonzalez-Alvarez, G.Alzuet, J.Borras, B.Macias, M.del Olmo, M.Liu-Gonzalez, F.Sanz|2002|J.Inorg.Biochem.|89|29|doi:10.1016/S0162-0134(01)00369-5
CCDC 173866: Experimental Crystal Structure Determination
Related Article: B.Macias, I.Garcia, M.V.Villa, J.Borras, A.Castineiras, F.Sanz|2002|Polyhedron|21|1229|doi:10.1016/S0277-5387(02)00997-X
CCDC 278682: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, M.Salgado, J.Borras, M.Gonzalez-Alvarez, F.Sanz|2006|Inorg.Chim.Acta|359|1465|doi:10.1016/j.ica.2005.11.032
CCDC 1519195: Experimental Crystal Structure Determination
Related Article: Y. Hernández, I.S. Marcos, N.M. Garrido, F. Sanz, D. Diez|2017|Acta Crystallogr.,Sect.E:Cryst.Commun.|73|85|doi:10.1107/S2056989016019952
CCDC 866169: Experimental Crystal Structure Determination
Related Article: C.Andreu, F.Sanz, G.Asensio|2012|Eur.J.Org.Chem.|2012|4185|doi:10.1002/ejoc.201200430
CCDC 644681: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, L.Sanchez-Mesonero, F.Sanz, J.Borras, M.Gonzalez-Alvarez|2007|Z.Anorg.Allg.Chem.|633|1937|doi:10.1002/zaac.200700318
CCDC 173676: Experimental Crystal Structure Determination
Related Article: B.Macias, I.Garcia, M.V.Villa, J.Borras, A.Castineiras, F.Sanz|2002|Polyhedron|21|1229|doi:10.1016/S0277-5387(02)00997-X
CCDC 837873: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, R.Lapresa, G.Alzuet, J.Hernandez-Gil, F.Sanz|2012|J.Inorg.Biochem.|115|64|doi:10.1016/j.jinorgbio.2012.05.019
CCDC 837871: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, R.Lapresa, G.Alzuet, J.Hernandez-Gil, F.Sanz|2012|J.Inorg.Biochem.|115|64|doi:10.1016/j.jinorgbio.2012.05.019
CCDC 210649: Experimental Crystal Structure Determination
Related Article: J.Perez, L.Garcia, E.Perez, J.L.Serrano, J.F.Martinez, G.Sanchez, G.Lopez, A.Espinosa, M.Liu, F.Sanz|2003|New J.Chem.|27|1490|doi:10.1039/b302653a
CCDC 245525: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, F.Sanz, J.Borras, M.Gonzalez-Alvarez, G.Alzuet|2005|J.Inorg.Biochem.|99|1441|doi:10.1016/j.jinorgbio.2005.04.001
CCDC 278681: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, M.Salgado, J.Borras, M.Gonzalez-Alvarez, F.Sanz|2006|Inorg.Chim.Acta|359|1465|doi:10.1016/j.ica.2005.11.032
CCDC 837869: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, R.Lapresa, G.Alzuet, J.Hernandez-Gil, F.Sanz|2012|J.Inorg.Biochem.|115|64|doi:10.1016/j.jinorgbio.2012.05.019
CCDC 837870: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, R.Lapresa, G.Alzuet, J.Hernandez-Gil, F.Sanz|2012|J.Inorg.Biochem.|115|64|doi:10.1016/j.jinorgbio.2012.05.019
CCDC 644680: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, L.Sanchez-Mesonero, F.Sanz, J.Borras, M.Gonzalez-Alvarez|2007|Z.Anorg.Allg.Chem.|633|1937|doi:10.1002/zaac.200700318
CCDC 173677: Experimental Crystal Structure Determination
Related Article: B.Macias, I.Garcia, M.V.Villa, J.Borras, A.Castineiras, F.Sanz|2002|Polyhedron|21|1229|doi:10.1016/S0277-5387(02)00997-X
CCDC 150109: Experimental Crystal Structure Determination
Related Article: L.Gutierrez, G.Alzuet, J.Borras, M.Liu-Gonzalez, F.Sanz, A.Castineiras|2001|Polyhedron|20|703|doi:10.1016/S0277-5387(01)00717-3
CCDC 866170: Experimental Crystal Structure Determination
Related Article: C.Andreu, F.Sanz, G.Asensio|2012|Eur.J.Org.Chem.|2012|4185|doi:10.1002/ejoc.201200430
CCDC 644679: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, L.Sanchez-Mesonero, F.Sanz, J.Borras, M.Gonzalez-Alvarez|2007|Z.Anorg.Allg.Chem.|633|1937|doi:10.1002/zaac.200700318
CCDC 278680: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, M.Salgado, J.Borras, M.Gonzalez-Alvarez, F.Sanz|2006|Inorg.Chim.Acta|359|1465|doi:10.1016/j.ica.2005.11.032
CCDC 866168: Experimental Crystal Structure Determination
Related Article: C.Andreu, F.Sanz, G.Asensio|2012|Eur.J.Org.Chem.|2012|4185|doi:10.1002/ejoc.201200430
CCDC 837872: Experimental Crystal Structure Determination
Related Article: B.Macias, M.V.Villa, R.Lapresa, G.Alzuet, J.Hernandez-Gil, F.Sanz|2012|J.Inorg.Biochem.|115|64|doi:10.1016/j.jinorgbio.2012.05.019
CCDC 150111: Experimental Crystal Structure Determination
Related Article: L.Gutierrez, G.Alzuet, J.Borras, M.Liu-Gonzalez, F.Sanz, A.Castineiras|2001|Polyhedron|20|703|doi:10.1016/S0277-5387(01)00717-3
CCDC 210650: Experimental Crystal Structure Determination
Related Article: J.Perez, L.Garcia, E.Perez, J.L.Serrano, J.F.Martinez, G.Sanchez, G.Lopez, A.Espinosa, M.Liu, F.Sanz|2003|New J.Chem.|27|1490|doi:10.1039/b302653a