Author: Andrea Ferraro

0000000000288527

AUTHOR

Andrea Ferraro

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Tumor response assessment by modified Choi criteria in localized high-risk soft tissue sarcoma treated with chemotherapy.

2012

BACKGROUND. The objective of this study was to compare the prognostic relevance of Response Evaluation Criteria in Solid Tumors (RECIST) versus Choi criteria for the assessment of response in patients with high-risk soft tissue sarcoma of the extremities or trunk wall who received preoperative chemotherapy with or without radiotherapy in a phase 3 trial. METHODS. Patients received 3 cycles of preoperative epirubicin þ ifosfamide with or without radiotherapy. The diagnostic concordance between RECIST and Choi criteria and their correlation with overall survival (OS) and freedom from progression (FFP) were evaluated in a univariate Cox regression model. RESULTS. In 243 of 321 eligible patient…

RiskCancer Researchmedicine.medical_specialtymedicine.medical_treatmentchemotherapymedicineHumansResponse Evaluation Criteria in Solid TumorsProbabilityProportional Hazards ModelsRetrospective Studiesresponse assessmentIfosfamideProportional hazards modelbusiness.industrySoft tissue sarcomachemotherapy; Choi criteria; outcome; prognosis; response assessment; Response Evaluation Criteria in Solid Tumors; sarcoma; Cancer Research; OncologySarcomamedicine.diseasePrognosisSurgeryRadiation therapyChoi criteriaOncologyResponse Evaluation Criteria in Solid TumorsoutcomeRadiologySarcomabusinessProgressive diseasemedicine.drugEpirubicinCancer

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