0000000000289260

AUTHOR

Manuela Mihalache

showing 2 related works from this author

Evaluation of thrombin generation in classical Philadelphianegative myeloproliferative neoplasms / Evaluarea generării trombinei în neoplasmele mielo…

2016

Abstract Introduction: Patients with Philadelphia-negative chronic myeloproliferative neoplasms (Ph-MPN), polycytemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF), are prone to develop thrombotic events. We aimed to investigate the coagulation status in their plasma using thrombin generation assay (TGA), a functional global assay, on Ceveron® Alpha. Materials and methods: The samples were collected from 89 consecutive Ph-negative MPN patients and from 78 controls into K2EDTA and CTAD tubes for blood cell counts, TGA and coagulation screening tests. Thrombin generation was analysed in platelet-poor plasma using Technothrombin® TGA assay kit. Results: We found a …

Philadelphia negativeessential thrombocythemiaidiopatic myelofibrosisbusiness.industryR030204 cardiovascular system & hematologyThrombin generation03 medical and health sciences0302 clinical medicinepolycythemia verahemic and lymphatic diseasesthrombin generationCancer researchMedicineMedicinebusinessthrombosis030215 immunologyRomanian Journal of Laboratory Medicine
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bbFISH-ing in the sonication fluid

2019

Abstract By 2030, the annual number of combined total hip and knee arthroplasty is estimated to reach 3.5 to 4 million in the US alone. In the context of a constant increase of the number of primary and revision total hip and knee arthroplasty, an increased risk of complication is expected. Prosthetic joint infections (PJIs) represent major cause of healthcare expenditure and morbidity. PJI still remain the most common and feared arthroplasty complication. A rapid and correct diagnosis of infection is decisive for a correct therapeutical management. In this setting, the Academic Emergency Hospital Sibiu adopted and implemented, with the beginning of September 2016, a new strategy for the di…

sonicationMaleProsthetic joint infectionmedicine.medical_specialtyPJIProsthesis-Related InfectionsArthroplasty Replacement Hipmedicine.medical_treatmentSonication7100Observational StudydiagnosticContext (language use)biofilm03 medical and health sciences0302 clinical medicineStaphylococcus epidermidisRNA Ribosomal 16SInternal medicineSynovial FluidmedicineHumans030212 general & internal medicineArthroplasty Replacement KneeIn Situ Hybridization FluorescenceAgedAged 80 and overBacteriological Techniquesbiologybusiness.industryRalstonia pickettiimolecular diagnosticBacterial InfectionsGeneral MedicineGold standard (test)Middle Agedbiology.organism_classificationArthroplastyRNA BacterialConnective Tissue030220 oncology & carcinogenesisPositive culturebbFISHFemaleComplicationbusinessResearch ArticleMedicine
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