0000000000289601

AUTHOR

Paolo Erba

showing 3 related works from this author

Impact of platelet rich plasma and adipose stem cells on lymphangiogenesis in a murine tail lymphedema model.

2015

Abstract Background Lymphedema is an underdiagnosed pathology which in industrialized countries mainly affects cancer patients that underwent lymph node dissection and/or radiation. Currently no effective therapy is available so that patients' life quality is compromised by swellings of the concerned body region. This unfortunate condition is associated with body imbalance and subsequent osteochondral deformations and impaired function as well as with an increased risk of potentially life threatening soft tissue infections. Methods The effects of PRP and ASC on angiogenesis (anti-CD31 staining), microcirculation (Laser Doppler Imaging), lymphangiogenesis (anti-LYVE1 staining), microvascular…

MaleTailPathologymedicine.medical_specialtyAngiogenesisCorrosion CastingMesenchymal Stem Cell TransplantationBiochemistryMicemedicineAnimalsHumansRegenerationLymphedemaLymphangiogenesisLymph nodeLymphatic Vesselsbusiness.industryPlatelet-Rich PlasmaCell Biologymedicine.diseaseLymphangiogenesisMice Inbred C57BLAdult Stem CellsDisease Models Animalmedicine.anatomical_structureLymphedemaLymphatic systemAdipose TissuePlatelet-rich plasmaMicroscopy Electron ScanningBody regionCardiology and Cardiovascular MedicineWound healingbusinessMicrovascular research
researchProduct

Angiogenesis in Wounds Treated by Microdeformational Wound Therapy.

2011

BACKGROUND:: Mechanical forces play an important role in tissue neovascularization and are a constituent part of modern wound therapies. The mechanisms by which vacuum assisted closure (VAC) modulates wound angiogenesis are still largely unknown. OBJECTIVE:: To investigate how VAC treatment affects wound hypoxia and related profiles of angiogenic factors as well as to identify the anatomical characteristics of the resultant, newly formed vessels. METHODS:: Wound neovascularization was evaluated by morphometric analysis of CD31-stained wound cross-sections as well as by corrosion casting analysis. Wound hypoxia and mRNA expression of HIF-1α and associated angiogenic factors were evaluated by…

MaleVascular Endothelial Growth Factor APathologymedicine.medical_specialtyWound therapyAngiogenesismedicine.medical_treatmentNeovascularization PhysiologicOcclusive DressingsArticleNeovascularizationMiceNegative-pressure wound therapymedicineAnimalsSkinWound Healingintegumentary systemReverse Transcriptase Polymerase Chain Reactionbusiness.industryGranulation tissueBiomechanical PhenomenaMice Inbred C57BLOxygenPlatelet Endothelial Cell Adhesion Molecule-1Occlusive dressingVascular endothelial growth factor Amedicine.anatomical_structureMicrovesselsGranulation TissueCancer researchSurgerymedicine.symptombusinessWound healingNegative-Pressure Wound Therapy
researchProduct

Donor site morbidity of the posterior conchal region.

2009

BACKGROUND The perichondral cutaneous graft (PCCG) from the posterior conchal region is an elegant solution for the coverage of facial defects with particular stability requirements. The donor defect can easily be covered with a transposition flap from the postauricular region. Although this region is a common donor site for skin grafts and has an important supporting function for glasses or hearing aids, little is known about long-term morbidity after graft harvest. OBJECTIVE To assess the morbidity of the posterior concha and the postauricular region in terms of pain, scar formation, and patient satisfaction. MATERIALS AND METHODS A retrospective study of 16 patients who had a PCCG harves…

Malemedicine.medical_specialtyTime FactorsDermatologyTurbinatesSurgical FlapsKeloidPatient satisfactionear reconstructionmedicineHumansAgedRetrospective StudiesPostauricular regionWound dehiscencebusiness.industrydonor siteHyperesthesiaRetrospective cohort studyGeneral MedicineSkin Transplantationcomposite graftPlastic Surgery Proceduresmedicine.diseaseTissue DonorsSurgeryTreatment OutcomePatient SatisfactionSurgeryFemalemedicine.symptombusinessFollow-Up StudiesDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
researchProduct