Author: Rodolfo Schrepfer

0000000000292332

AUTHOR

Rodolfo Schrepfer

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SUPRAMOLECULAR ASSOCIATION OF RECOMBINANT HUMAN GROWTH HORMONE WITH HYDROPHOBIZED POLYHYDROXYETHYLASPARTAMIDES

2008

Abstract The protein delivery properties of polymer supramolecular assemblies were investigated by using recombinant human growth hormone (rh-GH) and two polyhydroxyethylaspartamide (PHEA) derivatives: (a) PHEA-C 16 obtained by PHEA random grafting with hexadecylalkylamine; (b) PHEA-PEG 5000 -C 16 obtained by PHEA random co-grafting with hexadecylalkylamine and 5 kDa poly(ethylene glycol). The two polymers possessed similar self-assembling properties: critical micelle concentration (CMC) and particle size. The protein loading (protein/polymer, w/w, %) was 12.1 ± 1.3% and 8.5 ± 0.4% with PHEA-C 16 and PHEA-PEG 5000 -C 16 , respectively. The rh-GH/polymer association constant calculated by Sc…

Malechemistry.chemical_classificationHuman Growth HormoneSupramolecular chemistryPharmaceutical ScienceGeneral MedicinePolymerProtein delivery supramolecular assembly growth hormone polyhydroxyethylaspartamideDissociation (chemistry)Polyethylene GlycolsRatsSupramolecular assemblychemistry.chemical_compoundDrug Delivery SystemschemistryPolymer ratioCritical micelle concentrationAnimalsOrganic chemistryPeptidesDrug carrierEthylene glycolCells CulturedBiotechnologyNuclear chemistry

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