0000000000292483
AUTHOR
Jonathan Booth
A Review of 2000 Years of Paleoclimatic Evidence in the Mediterranean
[EN] The integration of climate information from instrumental data and documentary and natural archives; evidence of past human activity derived from historical, paleoecological, and archaeological records; and new climate modeling techniques promises major breakthroughs for our understanding of climate sensitivity, ecological processes, environmental response, and human impact. In this chapter, we review the availability and potential of instrumental data, less well-known written records, and terrestrial and marine natural proxy archives for climate in the Mediterranean region over the last 2000 years. We highlight the need to integrate these different proxy archives and the importance for…
An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs.
[BACKGROUND & AIMS] Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intra-hepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA of PBC to date, aiming to identify additional risk loci and prioritise candidate genes for in silico drug efficacy screening. [METHODS] We combined new and existing genotype data for 10, 516 cases and 20, 77…