0000000000293459
AUTHOR
P. Sanz
Implantation of bilayered plla scaffolds loaded with mesenchymal stem cells (MSCS) in a sheep model of osteochondral lesions
[EN] Purpose: Cartilage injuries are poorly repaired after surgery, since cartilage is a tissue with a very limited capacity to regenerate. Apart from other surgical attempts, autologous chondrocyte implantation (ACI) was the first cell therapy approach developed for these kinds of lesions. Chondrocyte usage nevertheless is limited by the dedifferentiation occurred when expanded in monolayer. Bone marrow-derived Mesenchymal Stem Cells (MSC) emerge as ideal cells to be implanted in the site of cartilage lesions. Methods: Here we use MSC to treat sheep cartilage lesions implanted in the upper cartilage layer of bilayered PLLA scaffolds, which hold a lower layer enriched with Hydroxiapatite to…
Influenza vaccine effectiveness in preventing outpatient, inpatient, and severe cases of laboratory-confirmed influenza.
Background. In most seasons, the influenza vaccine is effective in preventing influenza, but it is not clear whether it is equally effective in preventing mild and severe cases. We designed a case-control study to compare the effectiveness of the influenza vaccine in preventing outpatient, inpatient, and severe or fatal cases of laboratory-confirmed influenza. Methods. Hospitalized patients (n = 691) with laboratory-confirmed influenza in the 2010–2011 season recruited in 29 Spanish hospitals were individually matched by age, admission/visit date, and province with an outpatient with laboratory-confirmed influenza and an outpatient control. Severe cases were considered those patients admitt…
Factores que afectan al análisis biológico de las muestras de agresiones sexuales
El concepto multidisciplinar de Ciencias Forenses se ha consolidado en los últimos años integrando un amplio espectro de profesionales de distintas disciplinas que ha abierto nuevas áreas de trabajo, en la mayoría de las cuales la interpretación del resultado se basa en la comparación con un material de referencia. Este trabajo pretende exponer brevemente una revisión de la casuística de Delitos Contra la Libertad Sexual (DCLS) estudiados en los laboratorios de Biología Forense y evaluar el rendimiento de la prueba de ADN a lo largo de los años en dos aspectos: uno en las situaciones inherentes a la metodología y otro en lo que respecta al cotejo de los vestigios analizados con las muestras…