0000000000293963

AUTHOR

Valery P. Zakharov

0000-0002-0597-3122

showing 2 related works from this author

Multispectral autoflourescence detection of skin neoplasia using steady-state techniques

2019

In the current study were used excitation-emission matrices (EEMs) and synchronous fluorescence spectroscopy (SFS) steady-state techniques in a broad spectral regions (excitation at 220-500 nm and emission at 280-850 nm) to achieve the whole set of endogenous fluorophores, existed in normal and neoplastic cutaneous tissues. Several types of benign, dysplastic and malignant types of skin lesions were investigated ex vivo using both EEM and SFS modalities, namely the basal cell papilloma and carcinoma, pigmented nevi, dysplastic nevi, squamous cell carcinoma and malignant melanoma. Histological analysis was used as a “gold standard” for evaluation of clinical diagnosis of the lesions investig…

chemistry.chemical_classificationPathologymedicine.medical_specialtyskin cancerbiologyChemistryMelanomamedicine.diseaseendogenous fluorophoresMelaninAutofluorescenceKeratinexcitation-emission matrixmedicineCarcinomabiology.proteinPapillomaSkin cancerElastinsynchronous fluorescence spectroscopy20th International Conference and School on Quantum Electronics: Laser Physics and Applications
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Multispectral fluorescence detection of pigmented cutaneous tumours

2020

We investigated pigmented skin tumour lesions in vivo and ex vivo, including benign and dysplastic nevi, as well as malignant lesions, such as pigmented basal cell carcinoma (BCC) and malignant melanoma (MM) lesions, to obtain a complex view about the feasibility of different excitation sources solely and/or in combination to induce fluorescence signal useful for diagnosis of various low-fluorescent cutaneous neoplasia. A specialized multispectral analysis of the data obtained was applied by using excitation in broad spectral range, covering ultraviolet, visible and near-infrared spectral range, that contribute considerably to: (1) fundamental determination of tumour tissues’ spectral prope…

chemistry.chemical_classificationintegumentary systembiologyChemistryMelanomamedicine.diseaseFluorescenceMolecular biologyMelaninIn vivoKeratinmedicinebiology.proteinBasal cell carcinomaSkin cancerElastinBiophotonics—Riga 2020
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