0000000000295168

AUTHOR

Denise Whitby

showing 7 related works from this author

Risk of Classic Kaposi Sarcoma With Combinations of Killer Immunoglobulin-Like Receptor and Human Leukocyte Antigen Loci: A Population-Based Case-con…

2015

BACKGROUND Kaposi sarcoma (KS) is a complication of KS-associated herpesvirus (KSHV) infection. Other oncogenic viral infections and malignancies are associated with certain HLA alleles and their natural killer (NK) cell immunoglobulin-like receptor (KIR) ligands. We tested whether HLA-KIR influences the risk of KSHV infection or KS. METHODS In population-based case-control studies, we compared HLA class I and KIR gene frequencies in 250 classic (non-AIDS) KS cases, 280 KSHV-seropositive controls, and 576 KSHV-seronegative controls composing discovery and validation cohorts. Logistic regression was used to calculate sex- and age-adjusted odds ratios (ORs) and 95% confidence intervals. RESUL…

0301 basic medicineGenotypevirusescase-control studyPopulationchemical and pharmacologic phenomenaHuman leukocyte antigenBiologyLymphocyte ActivationSettore MED/42 - Igiene Generale E ApplicataMajor Articles and Brief Reports03 medical and health sciencesReceptors KIRnatural killer–cell immunoglobulin-like receptorsHLA AntigensRisk FactorsSeroepidemiologic Studieshuman leukocyte antigenGenotypeotorhinolaryngologic diseasesHLA-B AntigensHumansImmunology and AllergySeroprevalenceGenetic Predisposition to Diseasehuman geneticeducationSarcoma Kaposieducation.field_of_studyClassic Kaposi SarcomaCase-control studyvirus diseasesKaposi sarcomaOdds ratiomajor histocompatibility complex030104 developmental biologyInfectious DiseasesGene Expression RegulationItalyCase-Control StudiesItaly; Kaposi sarcoma; case-control study; human genetics; human leukocyte antigens; major histocompatibility complex; natural killer–cell immunoglobulin-like receptorsHerpesvirus 8 HumanImmunologyJournal of Infectious Diseases
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Host immunogenetics and control of human herpesvirus-8 infection

2006

BACKGROUND: Kaposi sarcoma (KS) is primarily caused by human herpesvirus (HHV)-8 infection, and the risk is increased with high HHV-8 lytic or latent antibody titers or the detection of HHV-8 DNA in peripheral blood mononuclear cells (PBMCs). Host genes important for control of HHV-8 infection are not well characterized. METHODS: In 172 HHV-8 latent nuclear antigen (LANA)-seropositive adults in Italy without KS, we examined correlations of common variants in host immune genes with the detection of HHV-8 DNA in PBMCs and with high lytic and latent antibody titers. Twenty-eight single-nucleotide polymorphisms in 14 genes were analyzed. We detected HHV-8 DNA in PBMCs with real-time amplificati…

AdultMaleVascular Endothelial Growth Factor ASimplexvirusfood.ingredientvirusesImmunogeneticsBiologymedicine.disease_causeAntibodies ViralHerpesviridaefoodAntigenLatent Nuclear AntigenRisk FactorsImmunogeneticsmedicineImmunology and AllergyHumansAgedAntibody titervirus diseasesHerpesviridae Infectionsbiochemical phenomena metabolism and nutritionMiddle AgedVirologyEditorial CommentaryTiterInfectious DiseasesLytic cycleHaplotypesImmunologyDNA ViralHerpesvirus 8 HumanLeukocytes MononuclearCytokinesFemale
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Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma.

2006

BACKGROUND Classic Kaposi sarcoma (CKS) is an inflammatory-mediated neoplasm that develops in the presence of KS-associated herpesvirus (KSHV) and immune perturbation. In the current study, the authors compared CKS cases with age-matched and sex-matched KSHV-seropositive controls without human immunodeficiency virus-1 infection and markers of viral control, blood counts, CD4-positive and CD8-positive lymphocytes, and serum β-2-microglobulin and neopterin levels. METHODS Viral loads were detected using real-time amplification of the KSHV-K6 and EBV-pol genes, anti-K8.1 (lytic) titers were detected by enzyme-linked immunoadsorbent assay, and antilatent nuclear antigen (LANA) titers were detec…

AdultMaleCancer ResearchHIV InfectionsHematocritmedicine.disease_causePeripheral blood mononuclear cellHerpesviridaechemistry.chemical_compoundAntigenRisk FactorsmedicineGammaherpesvirinaeHumansSarcoma KaposiAgedAged 80 and overmedicine.diagnostic_testbiologybusiness.industryAntibody titerNeopterinMiddle Agedbiology.organism_classificationKaposi Sarcoma human herpesvirus-8 immunityOncologychemistryItalyImmunologyMultivariate AnalysisDisease ProgressionHIV-1FemalebusinessViral loadBiomarkersCancer
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Risk Factors for Classical Kaposi Sarcoma in a Population-based Case-control Study in Sicily

2008

Abstract Background: Classical Kaposi sarcoma is a rare complication of Kaposi sarcoma-associated herpes virus (KSHV) infection. We conducted a population-based, frequency-matched case-control study in Sicily to further investigate the reported inverse relationship between smoking and classical Kaposi sarcoma and to identify other factors associated with altered risk. Methods: All incident, histologically confirmed classical Kaposi sarcoma cases in Sicily were eligible. A two-stage cluster sample design was applied to select population controls. KSHV seropositivity was determined using four antibody assays (K8.1 and orf73 enzyme immunoassays and two immunofluorenscence assays). Using SAS-ca…

AdultMalemedicine.medical_specialtyEpidemiologyPopulationSettore MED/42 - Igiene Generale E ApplicataArticleRisk FactorsInternal medicinemedicineCKS risk factors SicilyHumanseducationSarcoma KaposiSicilyAgedAged 80 and overeducation.field_of_studyChi-Square DistributionClassic Kaposi Sarcomabusiness.industryIncidenceIncidence (epidemiology)SmokingCase-control studyvirus diseasesCancerOdds ratioMiddle Agedmedicine.disease/dk/atira/pure/subjectarea/asjc/2700/2730Logistic ModelsOncologyCase-Control Studies/dk/atira/pure/subjectarea/asjc/2700/2713ImmunologyFemaleSarcomabusinessChi-squared distribution
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A Common Genetic Variant inFCGR3A-V158F and Risk of Kaposi Sarcoma Herpesvirus Infection and Classic Kaposi Sarcoma

2005

Associations of FCGR3A among men with HIV/acquired immunodeficiency syndrome suggest that host responses affect the pathogenesis of Kaposi sarcoma herpesvirus (KSHV) infection and risk of acquired immunodeficiency syndrome – associated Kaposi sarcoma. Using DNA from two HIV seronegative case-control populations in Italy, we examined whether the functional FCGR3A-V158F variant was associated with risk of KSHV infection or classic Kaposi sarcoma (CKS). In population I, we examined FCGR3A variants and risk of KSHV infection in 34 KSHV latent nuclear antigen (LANA)-seropositive and 120 LANAseronegative adults from Sardinia (52% male; median age, 45 years; range, 31-60), whereas in population II…

AdultMaleEpidemiologyPopulationmedicine.disease_causeVirusHerpesviridaeAcquired immunodeficiency syndrome (AIDS)Risk FactorsOdds RatiomedicineHumansRisk factoreducationSarcoma KaposiAgedAged 80 and overeducation.field_of_studyClassic Kaposi Sarcomabusiness.industryReceptors IgGCase-control studyGenetic Variationvirus diseasesHerpesviridae InfectionsOdds ratioMiddle Agedmedicine.diseaseVirologyItalyOncologyCase-Control StudiesHerpesvirus 8 HumanImmunologybusinessCancer Epidemiology, Biomarkers & Prevention
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Socio-economic and other correlates of Kaposi sarcoma-associated herpesvirus seroprevalence among older adults in Sicily.

2009

The virus that causes Kaposi sarcoma, KS-associated herpesvirus (KSHV, also known as human herpesvirus 8) has an unusual distribution and poorly characterized modes of transmission. To clarify these issues, socio-demographic correlates of KSHV seroprevalence were examined in a population-based study. In 1,154 randomly sampled adults (aged 32- 92, mean 71 years) throughout Sicily, KSHV antibodies were detected with four assays and a conservative algorithm. Seroprevalence was re-weighted to the population. Odds ratios with 95% confidence intervals (OR, CI) from multivariate logistic regression were used to estimate associations of seroprevalence with interview data. KSHV seroprevalence was 8.…

AdultMalemedicine.medical_specialtyPopulationLogistic regressionAntibodies ViralSettore MED/42 - Igiene Generale E ApplicataArticleSerologyRisk FactorsSeroepidemiologic StudiesVirologyEpidemiologymedicineSeroprevalenceGammaherpesvirinaeHumanseducationSicilyAgedAged 80 and overeducation.field_of_studybiologybusiness.industryOdds ratioHerpesviridae InfectionsMiddle Agedbiology.organism_classificationVirologyKSHV seroprevalence socio-economic correlates elderly SicilyConfidence intervalInfectious DiseasesSocioeconomic FactorsHerpesvirus 8 HumanFemalebusiness
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Antibodies against lytic and latent Kaposi's sarcoma-associated herpes virus antigens and lymphoma in the European EpiLymph case-control study.

2011

Background: Kaposi's sarcoma-associated herpes virus is associated with primary effusion lymphoma and multicentric Castleman's disease. Methods: Seropositivity to lytic and latent Kaposi's sarcoma herpes virus (KSHV) antigens were examined in 2083 lymphomas and 2013 controls from six European countries. Results: Antibodies against KSHV latent and lytic antigens were detectable in 4.5% and 3.4% of controls, respectively, and 3.6% of cases (P>0.05). The KSHV seropositivity was associated with splenic marginal zone lymphoma (SMZL) (odds ratio (OR)=4.11, 95% confidence interval (CI)=1.57–10.83) and multiple myeloma (OR=0.31, 95% CI=0.11–0.85). Conclusion: The KSHV is unlikely to contribute impo…

AdultMaleCancer ResearchAdolescentvirusesShort CommunicationserologylymphomaAntibodiesSerologyhuman herpes virus 8Young AdultHerpes virusAntigenhemic and lymphatic diseasesLymphoma Primary EffusionmedicineHumansChildKaposi's sarcomaAntigens ViralSarcoma KaposiAgedAged 80 and overbiologybusiness.industryCastleman DiseaseLymphoma Non-HodgkinCase-control studyInfant Newbornvirus diseasesInfantMiddle Agedmedicine.diseaseVirologyLymphomaEuropeOncologyLytic cycleKaposi's sarcoma-associated herpes virusCase-Control StudiesChild PreschoolImmunologyHerpesvirus 8 Humanbiology.proteinFemaleepidemiologyAntibodybusinessBritish journal of cancer
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