0000000000295783
AUTHOR
M Obradovic
Effects of obesity and estradiol on Na+/K+-ATPase and their relevance to cardiovascular diseases
Obesity is associated with aberrant sodium/potassium-ATPase (Na+/K+-ATPase) activity, apparently linked to hyperglycemic hyperinsulinemia, which may repress or inactivate the enzyme. The reduction of Na+/K+-ATPase activity in cardiac tissue induces myocyte death and cardiac dysfunction, leading to the development of myocardial dilation in animal models; this has also been documented in patients with heart failure (HF). During several pathological situations (cardiac insufficiency and HF) and in experimental models (obesity), the heart becomes more sensitive to the effect of cardiac glycosides, due to a decrease in Na+/K+-ATPase levels. The primary female sex steroid estradiol has long been …
New Data from Pleistocene deposit of S. Ciro cave
Quaternary fossil sites in Sicily have been known for a long time and all of them have a common story of human predation and manipulation. Hence, we illustrate the first electrical tomography applied to the study of a fossiliferous deposit in a cave in Sicily. The site investigated is the deposit inside the cave of San Ciro-Maredolce, near Palermo. This study aims to answer the following questions: is the geoelectric survey applicable to quaternary deposit of caves? is the deposit still existing or has been completely emptied? Here we show a ERT model (Electrical Resistivy Tomography) of deposit and possible anthropogenic interactions (presence of historic and\or illegal excavations) with t…