Bryophytes: a powerful source of biologically active compounds

Bryophytes are generally considered the first plants appeared on the Earth. Taxonomically, they are placed between Algae and Pteridophytes. The medicinal traditional use of bryophytes has been documented for a long time in many countries. Bryophytes contain numerous potentially useful compounds and strong antioxidative enzymatic machinery, which help them to cope up with extreme climates and stresses, and, in several cases, the total antioxidant amount was found higher than in other antioxidant common sources even if not yet fully known. Thus, a positive correlation between the folklore use and the scientific evaluation could generate an alternative source of novel medicinal compounds, whic…

Exploring nose-to-brain insulin delivery as a new strategy for the treatment of Alzheimer’s disease

A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IR signaling are involved in brain cognitive functions and their dysfunction is implicated in Alzheimer’s disease (AD) degeneration. Thus, administration of insulin could be a strategy for AD treatment. For this aim we designed, synthesized and characterized a nanogel system (NG) to deliver insulin to the brain, as a tool for the development of a new therapy for AD. A carboxyl-functionalized poly(N-vinyl pyrrolidone) nanogel system produced by high energy ionizing radiation was chosen as substrate for the covalent attachment of insulin or fluorescent molecules, relevant for its tracing

NOVEL AMPHIPHILIC COPOLYMERS BASED ON POLYASPARTAMIDE GRAFT WITH SQUALENE RESIDUES TO OBTAIN MICELLES AS COLLOIDAL DRUG CARRIERS.