0000000000298524

AUTHOR

Alice Santos

showing 2 related works from this author

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

2021

Background: To date, 750 000 patients with COVID-19 worldwide have required mechanical ventilation and thus are at high risk of acute brain dysfunction (coma and delirium). We aimed to investigate the prevalence of delirium and coma, and risk factors for delirium in critically ill patients with COVID-19, to aid the development of strategies to mitigate delirium and associated sequelae. Methods: This multicentre cohort study included 69 adult intensive care units (ICUs), across 14 countries. We included all patients (aged ≥18 years) admitted to participating ICUs with severe acute respiratory syndrome coronavirus 2 infection before April 28, 2020. Patients who were moribund or had life-suppo…

Pulmonary and Respiratory Medicinemedicine.medical_specialtymedicine.medical_treatmentcovid-19; deliriumOutcomesLower riskCritical IlnessTask-Force03 medical and health sciences0302 clinical medicinedeliriumSDG 3 - Good Health and Well-beingIntensive-Care-UnitIntensive careSettore MED/41 - ANESTESIOLOGIAmedicineSurvivors030212 general & internal medicineSimplified Acute Physiology ScoreMechaniically Ventilated PatientsEpitiomologyMechanical ventilationComaIntensive-Care-Unit Mechaniically Ventilated Patients Clinical practice Guidelines Critical Ilness Task-Force Sedation ICU Survivors Outcomes Epitiomologybusiness.industrycovidRetrospective cohort studyArticlesClinical practice Guidelinescovid delirium030228 respiratory systemcovid-19SedationICUEmergency medicineDeliriummedicine.symptombusinessCohort studyThe Lancet. Respiratory Medicine
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Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical…

2022

BACKGROUND: High intraoperative PEEP with recruitment manoeuvres may improve perioperative outcomes. We re-examined this question by conducting a patient-level meta-analysis of three clinical trials in adult patients at increased risk for postoperative pulmonary complications who underwent non-cardiothoracic and non-neurological surgery. METHODS: The three trials enrolled patients at 128 hospitals in 24 countries from February 2011 to February 2018. All patients received volume-controlled ventilation with low tidal volume. Analyses were performed using one-stage, two-level, mixed modelling (site as a random effect; trial as a fixed effect). The primary outcome was a composite of postoperati…

AdultLung Diseases*PEEP*postoperative pulmonary complicationsmechanical ventilationPositive-Pressure RespirationsurgeryAnesthesiology and Pain MedicinePostoperative ComplicationsTidal Volume*surgeryHumanspostoperative pulmonary complicationsPostoperative Period*mechanical ventilationmechanical ventilation; PEEP; postoperative pulmonary complications; surgery; Adult; Humans; Lung; Postoperative Complications; Postoperative Period; Randomized Controlled Trials as Topic; Tidal Volume; Lung Diseases; Positive-Pressure RespirationLungPEEPRandomized Controlled Trials as Topic
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