0000000000300871

AUTHOR

Lucien Guenot

showing 2 related works from this author

Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats

2003

International audience; The anticarcinogenic effect of garlic has been demonstrated in both epidemiologic and experimental studies. In this study, possible mechanisms involved in the anticarcinogenic effect of garlic consumption were assessed by determining its capacity to alter drug metabolizing enzymes, in relation with its alliin content. Rats were fed a diet for 2 weeks containing 5% garlic powders produced from bulbs grown on soils with different levels of sulfate fertilization and therefore containing differing amounts of alliin. Activities of several hepatic enzymes, which are important in carcinogen metabolism such cytochromes P450 (CYP) and phase II enzymes, were determined. Garlic…

S01 - Nutrition humaine - Considérations généralesMaleDiallyl disulfideAlliinPharmacognosyhttp://aims.fao.org/aos/agrovoc/c_11091chemistry.chemical_compound0302 clinical medicinehttp://aims.fao.org/aos/agrovoc/c_4395[SDV.IDA]Life Sciences [q-bio]/Food engineeringGlucuronosyltransferaseComputingMilieux_MISCELLANEOUSAilGlutathione Transferasechemistry.chemical_classification0303 health sciencesbiologyDiallyl disulfidehttp://aims.fao.org/aos/agrovoc/c_2603food and beveragesBiological activityCytochrome P-450 CYP2E1[SDV.IDA] Life Sciences [q-bio]/Food engineering3. Good healthBiochemistryLiver030220 oncology & carcinogenesisGeneral Agricultural and Biological SciencesAllium sativumDrug-metabolizing enzymesFoiehttp://aims.fao.org/aos/agrovoc/c_290Médicamenthttp://aims.fao.org/aos/agrovoc/c_25197Alliin03 medical and health scienceshttp://aims.fao.org/aos/agrovoc/c_2395Cytochrome P-450 CYP1A2Cytochrome P-450 CYP1A1AnimalsAnticarcinogenic AgentsCysteineRats WistarQ04 - Composition des produits alimentairesGarlic030304 developmental biologySantéCytochrome P450General ChemistryGlutathioneAllium sativumPropriété pharmacologiqueDietRatsEnzymechemistryEnzymebiology.proteinRAThttp://aims.fao.org/aos/agrovoc/c_3511http://aims.fao.org/aos/agrovoc/c_6464
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Different effects of flavonoids on cytochrome P450 3A4- dependent nifedipine oxidation in human liver microsomes

1995

National audience

[SDV.TOX] Life Sciences [q-bio]/Toxicology[SDV.TOX]Life Sciences [q-bio]/ToxicologyComputingMilieux_MISCELLANEOUS
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