0000000000300871
AUTHOR
Lucien Guenot
Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats
International audience; The anticarcinogenic effect of garlic has been demonstrated in both epidemiologic and experimental studies. In this study, possible mechanisms involved in the anticarcinogenic effect of garlic consumption were assessed by determining its capacity to alter drug metabolizing enzymes, in relation with its alliin content. Rats were fed a diet for 2 weeks containing 5% garlic powders produced from bulbs grown on soils with different levels of sulfate fertilization and therefore containing differing amounts of alliin. Activities of several hepatic enzymes, which are important in carcinogen metabolism such cytochromes P450 (CYP) and phase II enzymes, were determined. Garlic…
Different effects of flavonoids on cytochrome P450 3A4- dependent nifedipine oxidation in human liver microsomes
National audience