Cholecystokinin-induced modulation of sensory-motor cortical excitability: effects of the interaction with 7-nitroindazole

Nitric oxide influence of cell excitability: comparison between cortical and smooth muscle cells.

INHIBITORY EFFECT OF CAFFEIC ACID PHENETHYL ESTER ON INTESTINAL MOTILITY

Inhibitory effect of caffeic acid phenethyl ester, a plant-derived polyphenolic compound, on rat intestinal contractility

Abstract Caffeic acid phenethyl ester (CAPE) exerts pharmacological actions (e.g. anti-inflammatory, chemopreventive) which are relevant for potential clinical application in the digestive tract. However, no study has been published on its possible effects on intestinal motility, to date. In the present study, we investigated the effect of this plant-derived polyphenolic compound on the spontaneous contractions of the rat isolated ileum. CAPE reduced (in a tetrodotoxin-insensitive manner) spontaneous ileal contractions and this effect was reduced by the l -type Ca 2+ channel blocker nifedipine and the chelant of calcium ethylenediaminetetraacetic acid. However, the effect of CAPE was not mo…

Celiac disease: a cause of unexplained elevated serum pancreatic enzymes