0000000000304801

AUTHOR

Michele D. Mignogna

showing 8 related works from this author

Proceedings of the Closed Round Table and Italian Consensus on the Medication-Related Osteonecrosis of Jaws (MRONJ) at the Symposium of Italian Socie…

2019

Part iiimedicine.medical_specialtyRound tablebusiness.industryPhysiologyGeneral surgeryPhysiology (medical)Oral and maxillofacial pathologymedicineItalian Consensus Medication-Related OsteoNecrosis of Jaws MRONJmedicine.diseasebusiness
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Assessment of sleep disturbance in oral lichen planus and validation of PSQI: A case-control multicenter study from the SIPMO (Italian Society of Ora…

2021

Background: The wellbeing of oral lichen planus patients (OLPs) may be strongly influenced by a poor quality of sleep (QoS) and psychological impairment. The aims were to analyze the prevalence of sleep disturbance, anxiety, and depression in OLPs and to validate the Pittsburgh Sleep Quality Index (PSQI) in OLPs. Methods: Three hundred keratotic OLPs (K-OLPs), 300 with predominant non-keratotic OLP (nK-OLPs), and 300 controls were recruited in 15 Italian universities. The PSQI, Epworth Sleepiness Scale (ESS), Hamilton Rating Scales for Depression and Anxiety (HAM-D and HAM-A), Numeric Rating Scale (NRS), and Total Pain Rating Index (T-PRI) were administered. Results: Oral lichen planus pati…

OralSleep Wake DisordersCancer Researchmedicine.medical_specialtyanxiety; insomnia; mood disturbance; oral lichen planus; sleep disturbance; Anxiety; Case-Control Studies; Depression; Female; Humans; Pathology Oral; Reproducibility of Results; Sleep; Surveys and Questionnaires; Lichen Planus Oral; Sleep Wake DisordersinsomniaReproducibility of Resultoral lichen planuPathology and Forensic MedicineSettore MED/28 - MALATTIE ODONTOSTOMATOLOGICHEPittsburgh Sleep Quality Indexoral lichen planusstomatognathic systemSurveys and QuestionnairesInsomniamedicineNumeric Rating ScalePathologySurveys and QuestionnaireHumansanxiety; insomnia; mood disturbance; oral lichen planus; sleep disturbancemood disturbanceSleep disorderbusiness.industryDepressionEpworth Sleepiness ScaleLichen PlanusReproducibility of ResultsRating scales for depressionmedicine.diseaseanxietysleep disturbancehumanitiesstomatognathic diseasesOtorhinolaryngologyCase-Control StudiesPathology OralPhysical therapyPeriodonticsAnxietyOral lichen planusFemaleOral Surgerymedicine.symptomCase-Control StudiebusinessSleepHumanLichen Planus Oral
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Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020

2020

The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majority of dentists and oral surgeons involved in MRONJ prevention (primary and secondary). The present paper reports the update of the conclusions from the Consensus Conference—held at the Symposium of the Italian Society of Oral Pathology and Medicine (SIPMO) (20 October 2018, Ancona, Italy)—after the newest recommendations (2020) on MRONJ were published by two scientific societies (Italian Societies of Maxillofacial Surgery and Oral Pathology and Medicine, SI…

bisphosphonateOral SurgeonHealth Toxicology and Mutagenesislcsh:MedicineMRONJantiangiogenic agents; antiresorptive drugs; bisphosphonates; cancer; denosumab; dentistry; MRONJ; oral surgery; osteoporosis; prevention models; bisphosphonate-associated osteonecrosis of the jaw; bone density conservation agents; diphosphonates; humans; Italy; quality of life0302 clinical medicineprevention modelCancerantiangiogenic agentsdentistryBone Density Conservation AgentsDiphosphonatesConference ReportBisphosphonatesAntiresorptive DrugsDenosumabItaly030220 oncology & carcinogenesisBisphosphonate-Associated Osteonecrosis of the JawDenosumabmedicine.drugoral surgerymedicine.medical_specialtyOral surgery03 medical and health sciencesOral surgeryAntiangiogenic agentsOral and maxillofacial pathologymedicinecancerHumansantiangiogenic agentantiresorptive drugsIntensive care medicinePrevention modelsbisphosphonatesantiresorptive drugAntiangiogenic agentsbusiness.industrylcsh:RPublic Health Environmental and Occupational Healthdenosumab030206 dentistrymedicine.diseaseosteoporosisAntiresorptive drugsDentistryOsteoporosisprevention modelsbusinessAntiangiogenic agents; Antiresorptive drugs; Bisphosphonates; Cancer; Denosumab; Dentistry; MRONJ; Oral surgery; Osteoporosis; Prevention models
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Number 1Epithelial biology

2005

The oral mucous membrane has features similar to skin but also differs in several ways. This paper reviews the aspects of epithelial biology necessary for an understanding of the vesiculoerosive disorders.

Pathologymedicine.medical_specialtybiologyAdenomatous polyposis coliOral mucous membranemacromolecular substancesEpitheliummedicine.anatomical_structureOtorhinolaryngologyGSK-3Bullous Pemphigoid Antigenmedicinebiology.proteinCancer researchGeneral DentistryOral Diseases
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Psychological profile and unexpected pain in oral lichen planus: a case-control multicenter SIPMO study

2021

Objectives: To analyze psychological profiles, pain and oral symptoms in patients with oral lichen planus (OLP). Materials and methods: 300 patients with keratotic OLP (K-OLP; reticular, papular, plaque-like subtypes), 300 patients with predominant non-keratotic OLP (nK-OLP; erythematosus atrophic, erosive, ulcerative, bullous subtypes) and 300 controls were recruited in 15 universities. The number of oral sites involved and oral symptoms were recorded. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were administered. Results: Th…

medicine.medical_specialtyoral lichen planuPittsburgh Sleep Quality IndexSettore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE03 medical and health sciences0302 clinical medicineoral lichen planusstomatognathic systemmental disordersmedicineanxiety; depression; oral lichen planus; pain; sleep disturbancepainGeneral DentistrySleep disorderbusiness.industryEpworth Sleepiness ScaleRating scales for depression030206 dentistrymedicine.diseaseanxietysleep disturbanceDermatologyhumanitiesstomatognathic diseasesPeripheral neuropathyOtorhinolaryngologyMood disorders030220 oncology & carcinogenesisdepressionAnxietyOral lichen planusmedicine.symptombusiness
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The association between burning mouth syndrome and sleep disturbance: A case-control multicentre study

2018

Objectives: To investigate the quality of sleep and the psychological profiles of a large cohort of Italian patients with burning mouth syndrome (BMS) and to clarify the relationships between these variables and pain. Methods: In this case–control study, 200 patients with BMS vs an equal number of age- and sex-matched healthy controls, recruited in 10 universities, were enrolled. The Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Hamilton Rating Scale for Depression (HAM-D), Hamilton Rating Scale for Anxiety (HAM-A), Numeric Pain Intensity Scale (NRS) and Total Pain Rating Index (T-PRI) were administered. Descriptive statistics, including the Mann–Whitney U test and …

MaleAnxietyinsomnia symptomsPittsburgh Sleep Quality Indexanxiety burning insomnia symptoms mood disorders pain sleep0302 clinical medicinePrevalenceSleep Wake DisorderpainburningSleep disorderDepressionEpworth Sleepiness ScaleOtorhinolaryngology2734 Pathology and Forensic MedicineBurning mouth syndromeMiddle Agedanxietymood disordershumanitiesAnxietyFemalemedicine.symptomCase-Control StudieHumanAdultSleep Wake Disordersmedicine.medical_specialtyanxiety; burning; insomnia symptoms; mood disorders; pain; sleep; Otorhinolaryngology2734 Pathology and Forensic Medicine; Dentistry (all)anxiety; burning; insomnia symptoms; mood disorders; pain; sleepPainmood disorderBurning Mouth SyndromeSettore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE03 medical and health sciencesRating scaleinsomnia symptommedicineHumanssleepGeneral DentistryAgedbusiness.industryHamilton Rating Scale for Depression030206 dentistrymedicine.diseaseMoodOtorhinolaryngologyCase-Control StudiesDentistry (all)Physical therapybusinessSleep030217 neurology & neurosurgery
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Clinical Validation of 13-gene DNA Methylation Analysis from Oral Brushing: A Non Invasive Sampling Procedure for Early Detection of Oral Squamous Ce…

2019

In a recent study our research group described a non-invasive sampling procedure based on [...]

Oncologymedicine.medical_specialtyoral brushing;oral squamous cell carcinoma; quantitative DNA methylation analysisbusiness.industryEarly detectionSampling (statistics)oral brushingoral squamous cell carcinomaInternal medicineDNA methylationMedicinequantitative DNA methylation analysisBasal cellGene DNA Methylation Analysis Oral Brushing Non Invasive Sampling Early Detection Oral Squamous Cell CarcinomabusinessNon invasive samplingGeneThe XV National and III International Congress of the Italian Society of Oral Pathology and Medicine
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Clinical validation of 13-gene DNA methylation analysis in oral brushing samples for detection of oral carcinoma: an Italian multicenter study

2021

Background The aim of this Italian multicenter study was to evaluate the diagnostic performance of a minimally invasive method for the detection of oral squamous cell carcinoma (OSCC) based on 13-gene DNA methylation analysis in oral brushing samples. Methods Oral brushing specimens were collected in 11 oral medicine centers across Italy. Twenty brushing specimens were collected by each center, 10 from patients with OSCC, and 10 from healthy volunteers. DNA methylation analysis was performed in blindness, and each sample was determined as positive or negative based on a predefined cutoff value. Results DNA amplification failed in 4 of 220 (1.8%) samples. Of the specimens derived from patien…

0301 basic medicinemedicine.medical_specialtyBisulfite sequencingalgorithm; bisulfite sequencing; diagnostic test; oral brushing; oral squamous cell carcinoma; quantitative DNA methylation analysisGastroenterologyoral brushing03 medical and health sciences0302 clinical medicineInternal medicineHealthy volunteersCarcinomamedicineHumansquantitative DNA methylation analysisMouth neoplasmalgorithmbusiness.industryDNA Methylationmedicine.diseaseDna amplificationoral squamous cell carcinomastomatognathic diseases030104 developmental biologyItalyOtorhinolaryngologyMulticenter studyHead and Neck Neoplasmsdiagnostic test030220 oncology & carcinogenesisDNA methylationCarcinoma Squamous Cellbisulfite sequencingMouth NeoplasmsbusinessOral medicine
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