0000000000306180
AUTHOR
Giuseppe Curcurù
Epistemic uncertainty in fault tree analysis approached by the evidence theory
Abstract Process plants may be subjected to dangerous events. Different methodologies are nowadays employed to identify failure events, that can lead to severe accidents, and to assess the relative probability of occurrence. As for rare events reliability data are generally poor, leading to a partial or incomplete knowledge of the process, the classical probabilistic approach can not be successfully used. Such an uncertainty, called epistemic uncertainty, can be treated by means of different methodologies, alternative to the probabilistic one. In this work, the Evidence Theory or Dempster–Shafer theory (DST) is proposed to deal with this kind of uncertainty. In particular, the classical Fau…
Modeling of Hepatocytes Proliferation Isolated from Proximal and Distal Zones from Human Hepatocellular Carcinoma Lesion
Isolation of hepatocytes from cirrhotic human livers and subsequent primary culture are important new tools for laboratory research and cell-based therapeutics in the study of hepatocellular carcinoma (HCC). Using such techniques, we have previously identified different subpopulations of human hepatocytes and among them one is showing a progressive transformation of hepatocytes in HCC-like cells. We have hypothesized that increasing the distance from the neoplastic lesion might affect hepatocyte function and transformation capacity. However, limited information is available in comparing the growth and proliferation of human hepatocytes obtained from different areas of the same cirrhotic liv…
Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery
BACKGROUND: Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the theory that Hsp60 has potential as a biomarker as well as a therapeutic target in patients with large bowel cancer. METHODS: The authors studied a population of 97 subjects, including patients and controls. Immunomorphology, Western blot analysis, and quantitative real-time polymerase chain reaction were performed on tissue specimens. Exosomes were isolated from blood and characterized by electr…
Hazardous air pollutants and primary liver cancer in Texas.
The incidence of hepatocellular carcinoma (HCC), the most common primary liver cancer, is increasing in the US and tripled during the past two decades. The reasons for such phenomenon remain poorly understood. Texas is among continental states with the highest incidence of liver cancer with an annual increment of 5.7%. Established risk factors for HCC include Hepatitis B and C (HBV, HCV) viral infection, alcohol, tobacco and suspected risk factors include obesity and diabetes. While distribution of these risk factors in the state of Texas is similar to the national data and homogeneous, the incidence of HCC in this state is exceptionally higher than the national average and appears to be di…
An imprecise Fault Tree Analysis for the estimation of the Rate of OCcurrence Of Failure (ROCOF)
Abstract The paper proposes an imprecise Fault Tree Analysis in order to characterize systems affected by the lack of reliability data. Differently from other research works, the paper introduces a classification of basic events into two categories, namely Initiators and Enablers . Actually, in real industrial systems some events refer to component failures or process parameter deviations from normal operating conditions ( Initiators ), whereas others refer to the functioning of safety barriers to be activated on demand ( Enablers ). As a consequence, the output parameter of interest is not the classical probability of occurrence of the top event, but its Rate of OCcurrence (ROCOF) over a s…
A predictive maintenance policy with imperfect monitoring
For many systems,failure is a very dangerous or costly event. To reduce the occurrence of this event,it is necessary to implement a preventive maintenance policy to replace the critical elements before failure.Since elements do not often exhibit incipient faults, they are replaced before a complete exploiting of their useful life.To conjugate the objective of exploiting elements for almost all their useful life with the objective to avoid failure,condition based and,more recently,predictive maintenance policies have been proposed.This paper deals with this topic and proposes a procedure for the computation of the maintenance time that minimizes the global maintenance cost.By adopting a stoc…
Current Practices in the Management of Pulmonary Ground-Glass Opacities: A Survey of SICT Members
Background Several gray areas and controversies exist concerning the management of pulmonary ground-glass opacities (GGOs), and there is a lack of consensus among clinicians on this topic. One of the main aims of the Italian Society of Thoracic Surgery is to promote education and research, so we decided to perform a survey on this topic to estimate current trends in practice in a large sample of thoracic surgeons. Methods A total of 160 thoracic surgeons responded, namely, completed our questionnaire (response rate, 53%; 160 of 302). The survey was composed of 36 questions divided into six subsections: (1) demographic characteristics of the respondents; (2) terminology and taxonomy; (3) rad…