0000000000306640
AUTHOR
Wim T. Klooster
Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes featuring N-heterocyclic carbene and alkynyl ligands
Experimental organometallic gold(I) compounds hold promise for anticancer therapy. This study reports the synthesis of two novel families of gold(I) complexes, including N1-substituted bis-N-heterocyclic carbene (NHC) complexes of general formula [Au(N1-TBM) 2]BF 4 (N1-TBM = N1-substituted 9-methyltheobromin-8-ylidene) and mixed gold(I) NHC-alkynyl complexes, [Au(N1-TBM)alkynyl]. The compounds were fully characterised for their structure and stability in aqueous environment and in the presence of N-acetyl cysteine by nuclear magnetic resonance (NMR) spectroscopy. The structures of bis(1-ethyl-3,7,9-trimethylxanthin-8-ylidene)gold(I), (4-ethynylpyridine)(1,9-dimethyltheobromine-8-ylidene)gol…
Carbon–Phosphorus Coupling from C^N Cyclometalated Au III Complexes
Abstract With the aim of exploiting new organometallic species for cross‐coupling reactions, we report here on the AuIII‐mediated Caryl−P bond formation occurring upon reaction of C^N cyclometalated AuIII complexes with phosphines. The [Au(C^N)Cl2] complex 1 featuring the bidentate 2‐benzoylpyridine (CCON) scaffold was found to react with PTA (1,3,5‐triaza‐7‐phosphaadamantane) under mild conditions, including in water, to afford the corresponding phosphonium 5 through C−P reductive elimination. A mechanism is proposed for the title reaction based on in situ 31P{1H} NMR and HR‐ESI‐MS analyses combined with DFT calculations. The C−P coupling has been generalized to other C^N cyclometalated Au…
CCDC 1913564: Experimental Crystal Structure Determination
Related Article: Samuel M. Meier-Menches, Brech Aikman, Daniel Döllerer, Wim T. Klooster, Simon J. Coles, Nicolò Santi, Louis Luk, Angela Casini, Riccardo Bonsignore|2020|J.Inorg.Biochem.|202|110844|doi:10.1016/j.jinorgbio.2019.110844
CCDC 1941496: Experimental Crystal Structure Determination
Related Article: Riccardo Bonsignore, Sophie R. Thomas, Wim T. Klooster, Simon J. Coles, Robert L. Jenkins, Didier Bourissou, Giampaolo Barone, Angela Casini|2020|Chem.-Eur.J.|26|4226|doi:10.1002/chem.201905392
CCDC 1916760: Experimental Crystal Structure Determination
Related Article: Samuel M. Meier-Menches, Brech Aikman, Daniel Döllerer, Wim T. Klooster, Simon J. Coles, Nicolò Santi, Louis Luk, Angela Casini, Riccardo Bonsignore|2020|J.Inorg.Biochem.|202|110844|doi:10.1016/j.jinorgbio.2019.110844
CCDC 1941494: Experimental Crystal Structure Determination
Related Article: Riccardo Bonsignore, Sophie R. Thomas, Wim T. Klooster, Simon J. Coles, Robert L. Jenkins, Didier Bourissou, Giampaolo Barone, Angela Casini|2020|Chem.-Eur.J.|26|4226|doi:10.1002/chem.201905392
CCDC 1947336: Experimental Crystal Structure Determination
Related Article: Riccardo Bonsignore, Sophie R. Thomas, Wim T. Klooster, Simon J. Coles, Robert L. Jenkins, Didier Bourissou, Giampaolo Barone, Angela Casini|2020|Chem.-Eur.J.|26|4226|doi:10.1002/chem.201905392
CCDC 1968702: Experimental Crystal Structure Determination
Related Article: Riccardo Bonsignore, Sophie R. Thomas, Wim T. Klooster, Simon J. Coles, Robert L. Jenkins, Didier Bourissou, Giampaolo Barone, Angela Casini|2020|Chem.-Eur.J.|26|4226|doi:10.1002/chem.201905392
CCDC 1940532: Experimental Crystal Structure Determination
Related Article: Samuel M. Meier-Menches, Brech Aikman, Daniel Döllerer, Wim T. Klooster, Simon J. Coles, Nicolò Santi, Louis Luk, Angela Casini, Riccardo Bonsignore|2020|J.Inorg.Biochem.|202|110844|doi:10.1016/j.jinorgbio.2019.110844