0000000000306640

AUTHOR

Wim T. Klooster

showing 9 related works from this author

Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes featuring N-heterocycl…

2020

Experimental organometallic gold(I) compounds hold promise for anticancer therapy. This study reports the synthesis of two novel families of gold(I) complexes, including N1-substituted bis-N-heterocyclic carbene (NHC) complexes of general formula [Au(N1-TBM) 2]BF 4 (N1-TBM = N1-substituted 9-methyltheobromin-8-ylidene) and mixed gold(I) NHC-alkynyl complexes, [Au(N1-TBM)alkynyl]. The compounds were fully characterised for their structure and stability in aqueous environment and in the presence of N-acetyl cysteine by nuclear magnetic resonance (NMR) spectroscopy. The structures of bis(1-ethyl-3,7,9-trimethylxanthin-8-ylidene)gold(I), (4-ethynylpyridine)(1,9-dimethyltheobromine-8-ylidene)gol…

Circular dichroismStereochemistryAntineoplastic Agents010402 general chemistryG-quadruplexLigands01 natural sciencesBiochemistryInorganic Chemistrychemistry.chemical_compoundNeoplasmsMoietyGold(I) organometallicsHumansN-heterocyclic carbenesCancer010405 organic chemistryChemistryFluorescenceG-quadruplexes0104 chemical sciencesFörster resonance energy transferMCF-7 CellsBODIPYDrug Screening Assays AntitumorSelectivityCarbeneAlkynyl ligandsMethaneOrganogold Compounds
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Carbon–Phosphorus Coupling from C^N Cyclometalated Au III Complexes

2020

Abstract With the aim of exploiting new organometallic species for cross‐coupling reactions, we report here on the AuIII‐mediated Caryl−P bond formation occurring upon reaction of C^N cyclometalated AuIII complexes with phosphines. The [Au(C^N)Cl2] complex 1 featuring the bidentate 2‐benzoylpyridine (CCON) scaffold was found to react with PTA (1,3,5‐triaza‐7‐phosphaadamantane) under mild conditions, including in water, to afford the corresponding phosphonium 5 through C−P reductive elimination. A mechanism is proposed for the title reaction based on in situ 31P{1H} NMR and HR‐ESI‐MS analyses combined with DFT calculations. The C−P coupling has been generalized to other C^N cyclometalated Au…

Organometallic Chemistrygold(III) cyclometalataled compoundsDenticitygold(III) cyclometalated compoundschemistry.chemical_element010402 general chemistry01 natural sciencesMedicinal chemistryDFTCatalysisReductive eliminationchemistry.chemical_compoundcross-couplingcarbon-phosphorous bond[CHIM]Chemical SciencesReactivity (chemistry)Phosphonium010405 organic chemistryPhosphorusCommunicationOrganic Chemistryreductive eliminationGeneral ChemistryBond formationcross- couplingCommunications0104 chemical sciences3. Good healthddc:gold(III) cyclometalataled compoundchemistrySettore CHIM/03 - Chimica Generale E Inorganicadensity functional calculationscarbon–phosphorous bondCarbon
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CCDC 1913564: Experimental Crystal Structure Determination

2019

Related Article: Samuel M. Meier-Menches, Brech Aikman, Daniel Döllerer, Wim T. Klooster, Simon J. Coles, Nicolò Santi, Louis Luk, Angela Casini, Riccardo Bonsignore|2020|J.Inorg.Biochem.|202|110844|doi:10.1016/j.jinorgbio.2019.110844

Space GroupCrystallographyCrystal System[(pyridin-4-yl)ethynyl]-(1379-tetramethyl-26-dioxo-123679-hexahydro-8H-purin-8-ylidene)-gold(i) unknown solvateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1941496: Experimental Crystal Structure Determination

2020

Related Article: Riccardo Bonsignore, Sophie R. Thomas, Wim T. Klooster, Simon J. Coles, Robert L. Jenkins, Didier Bourissou, Giampaolo Barone, Angela Casini|2020|Chem.-Eur.J.|26|4226|doi:10.1002/chem.201905392

Space GroupCrystallographyCrystal SystemCrystal Structure7-{2-[(pyridin-2-yl)amino]phenyl}-135-triaza-7-phosphatricyclo[3.3.1.137]decan-7-ium hexafluorophosphateCell ParametersExperimental 3D Coordinates
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CCDC 1916760: Experimental Crystal Structure Determination

2019

Related Article: Samuel M. Meier-Menches, Brech Aikman, Daniel Döllerer, Wim T. Klooster, Simon J. Coles, Nicolò Santi, Louis Luk, Angela Casini, Riccardo Bonsignore|2020|J.Inorg.Biochem.|202|110844|doi:10.1016/j.jinorgbio.2019.110844

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersbis(1-ethyl-379-trimethyl-26-dioxo-236789-hexahydro-1H-purin-8-ylidene)-gold(i) tetrafluoroborate hydrateExperimental 3D Coordinates
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CCDC 1941494: Experimental Crystal Structure Determination

2020

Related Article: Riccardo Bonsignore, Sophie R. Thomas, Wim T. Klooster, Simon J. Coles, Robert L. Jenkins, Didier Bourissou, Giampaolo Barone, Angela Casini|2020|Chem.-Eur.J.|26|4226|doi:10.1002/chem.201905392

Space GroupCrystallography7-{2-[(pyridin-2-yl)methyl]phenyl}-135-triaza-7-phosphatricyclo[3.3.1.137]decan-7-ium hexafluorophosphateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1947336: Experimental Crystal Structure Determination

2020

Related Article: Riccardo Bonsignore, Sophie R. Thomas, Wim T. Klooster, Simon J. Coles, Robert L. Jenkins, Didier Bourissou, Giampaolo Barone, Angela Casini|2020|Chem.-Eur.J.|26|4226|doi:10.1002/chem.201905392

Space GroupCrystallographyCrystal System7-[2-(pyridine-2-carbonyl)phenyl]-135-triaza-7-phosphatricyclo[3.3.1.137]decan-7-ium hexafluorophosphateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1968702: Experimental Crystal Structure Determination

2020

Related Article: Riccardo Bonsignore, Sophie R. Thomas, Wim T. Klooster, Simon J. Coles, Robert L. Jenkins, Didier Bourissou, Giampaolo Barone, Angela Casini|2020|Chem.-Eur.J.|26|4226|doi:10.1002/chem.201905392

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterschloro-[2-(pyridine-2-carbonyl)phenyl]-bis(triphenylphosphine)-gold(iii) hexafluorophosphate ethyl acetate solvateExperimental 3D Coordinates
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CCDC 1940532: Experimental Crystal Structure Determination

2019

Related Article: Samuel M. Meier-Menches, Brech Aikman, Daniel Döllerer, Wim T. Klooster, Simon J. Coles, Nicolò Santi, Louis Luk, Angela Casini, Riccardo Bonsignore|2020|J.Inorg.Biochem.|202|110844|doi:10.1016/j.jinorgbio.2019.110844

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters([4-(28-diethyl-55-difluoro-1379-tetramethyl-5H-45-dipyrrolo[12-c:2'1'-f][132]diazaborinin-10-yl)phenyl]ethynyl)-(1379-tetramethyl-26-dioxo-236789-hexahydro-1H-purin-8-yl)-gold unknown solvateExperimental 3D Coordinates
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