0000000000308597
AUTHOR
Daniel Vaiman
showing 5 related works from this author
CIME: An integrative and multidisciplinary PNR-PE project on Chronic Impact of ED Mixture Exposure at environmental low doses on Reproduction, Develo…
2012
CIME: An integrative and multidisciplinary PNR-PE project on Chronic Impact of ED Mixture Exposure at environmental low doses on Reproduction, Development and Behavior. Colloque PNR-PE
Differential effects of perinatal, prepubertal or conception to adulthood exposures to a low dose mixture of genistein and vinclozolin on the genital…
2012
Differential effects of perinatal, prepubertal or conception to adulthood exposures to a low dose mixture of genistein and vinclozolin on the genital tract and fertility of male rats and their unexposed progeny. Colloque PNR-PE
The placenta: phenotypic and epigenetic modifications induced by Assisted Reproductive Technologies throughout pregnancy
2015
International audience; Today, there is growing interest in the potential epigenetic risk related to assisted reproductive technologies (ART). Much evidence in the literature supports the hypothesis that adverse pregnancy outcomes linked to ART are associated with abnormal trophoblastic invasion. The aim of this review is to investigate the relationship between epigenetic dysregulation caused by ART and subsequent placental response. The dialogue between the endometrium and the embryo is a crucial step to achieve successful trophoblastic invasion, thus ensuring a non-complicated pregnancy and healthy offspring. However, as described in this review, ART could impair both actors involved in t…
Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver
2020
International audience; Environmental pollution is increasingly considered an important factor involved in the obesity incidence. Endocrine disruptors (EDs) are important actors in the concept of DOHaD (Developmental Origins of Health and Disease), where epigenetic mechanisms play crucial roles. Bisphenol A (BPA), a monomer used in the manufacture of plastics and resins is one of the most studied obesogenic endocrine disruptor. Bisphenol S (BPS), a BPA substitute, has the same obesogenic properties, acting at low doses with a sex-specific effect following perinatal exposure. Since the liver is a major organ in regulating body lipid homeostasis, we investigated gene expression and DNA methyl…
Multigenerational study of the obesogen effects of bisphenol S after a perinatal exposure in C57BL6/J mice fed a high fat diet.
2021
International audience; Background : Bisphenol S is an endocrine disruptor exhibiting metabolic disturbances, especially following perinatal exposures. To date, no data are available on the obesogen effects of BPS in a mutligenerational issue.Objectives : We investigated obesogen effects of BPS in a multigenerational study by focusing on body weight, adipose tissue and plasma parameters in male and female mice.Methods : Pregnant C57BL6/J mice were exposed to BPS (1.5 μg/kg bw/day ie a human equivalent dose of 0.12 μg/kg bw/day) by drinking water from gestational day 0 to post natal day 21. All offsprings were fed with a high fat diet during 15 weeks. Body weight was monitored weekly and fat…