0000000000308710
AUTHOR
M. Guillemin
Implementation of routine sequential PET/MR of the rat heart in an in-line preclinical scanner
International audience
Validation of SiPM-based PET imaging for left ventricular volumes measurements in preclinical imaging: comparison with simultaneously-acquired cardiac magnetic resonance at 7T.
International audience
MANOTA: a promising bifunctional chelating agent for copper-64 immunoPET
International audience; Improved bifunctional chelating agents (BFC) are required for copper-64 radiolabelling of monoclonal antibodies (mAbs) under mild conditions to yield stable, target-specific imaging agents. Four different bifunctional chelating agents (BFC) were evaluated for Fab (Fragment antigen binding) conjugation and radiolabelling with copper-64. Two DOTA- (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and two NOTA- (1,4,7-triazacyclononane-1,4,7-triacetic acid) derivatives bearing a p-benzyl-isothiocyanate group were conjugated to Fab-trastuzumab - which targets the HER2/neu receptor - and the average number of chelators attached ranged from 2.4 to 4.3 macrocycles …