0000000000311285

AUTHOR

Griselda De Marco

0000-0003-2344-9348

showing 10 related works from this author

Respiratory chain polymorphisms and obesity in the Spanish population, a cross-sectional study

2019

ObjectiveTo study the association of genes involved in the mitochondrial respiratory chain (MRC) pathway with body mass index (BMI) and obesity risk.DesignThis work studies three cross-sectional populations from Spain, representing three provinces: HORTEGA (Valladolid, Northwest/Centre), SEGOVIA (Segovia, Northwest/centre) and PIZARRA (Malaga,South).SettingForty-eight single nucleotide polymorphisms (SNPs) from MRC genes were selected and genotyped by SNPlex method. Association studies with BMI and obesity risk were performed for each population. These associations were then verified by analysis of the studied population as a whole (3731 samples).ParticipantsA total of 3731 Caucasian indivi…

AdultMaleobesityGenotypeCross-sectional studyPopulationRespiratory chainmitochondrial respiratory chain030209 endocrinology & metabolismSingle-nucleotide polymorphismPolymorphism Single NucleotideWhite PeopleBody Mass IndexMitochondrial Proteins03 medical and health sciences0302 clinical medicineRisk FactorsMedicineHumans1506educationAlleles030304 developmental biologyGenetic associationAged0303 health scienceseducation.field_of_studybusiness.industryResearch1697Genetics and GenomicssnpGeneral MedicineMiddle Agedmedicine.diseaseObesityMitochondrial respiratory chainCross-Sectional StudiesElectron Transport Chain Complex ProteinsSpainFemalebusinessBody mass indexDemographyBMJ Open
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Arsenic exposure and human blood DNA methylation and hydroxymethylation profiles in two diverse populations from Bangladesh and Spain.

2021

Abstract Background Associations of arsenic (As) with the sum of 5-mC and 5-hmC levels have been reported; however, As exposure-related differences of the separated 5-mC and 5-hmC markers have rarely been studied. Methods In this study, we evaluated the association of arsenic exposure biomarkers and 5-mC and 5-hmC in 30 healthy men (43–55 years) from the Aragon Workers Health Study (AWHS) (Spain) and 31 healthy men (31–50 years) from the Folic Acid and Creatinine Trial (FACT) (Bangladesh). We conducted 5-mC and 5-hmC profiling using Infinium MethylationEPIC arrays, on paired standard and modified (ox-BS in AWHS and TAB in FACT) bisulfite converted blood DNA samples. Results The median for t…

MalePhysiologyDHPSUrineBiologyBiochemistryArticleArsenicEpigenesis Geneticchemistry.chemical_compoundmedicineHumansLectins C-TypeEpigeneticsGeneGeneral Environmental ScienceCreatinineBangladeshCancerNuclear ProteinsDNA Methylationmedicine.diseaseBisulfitechemistrySpainReceptors MitogenDNA methylationEnvironmental research
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Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain.

2018

Inorganic arsenic exposure may be associated with diabetes, but the evidence at low-moderate levels is not sufficient. Polymorphisms in diabetes-related genes have been involved in diabetes risk. We evaluated the association of inorganic arsenic exposure on diabetes in the Hortega Study, a representative sample of a general population from Valladolid, Spain. Total urine arsenic was measured in 1,451 adults. Urine arsenic speciation was available in 295 randomly selected participants. To account for the confounding introduced by non-toxic seafood arsenicals, we designed a multiple imputation model to predict the missing arsenobetaine levels. The prevalence of diabetes was 8.3%. The geometric…

0301 basic medicineinorganic chemicalsAdultMaleRiskDiabetes riskHealth Toxicology and MutagenesisPopulationPhysiologychemistry.chemical_elementUrine010501 environmental sciencesToxicology01 natural sciencesArsenicalsArticleArsenic03 medical and health scienceschemistry.chemical_compoundYoung AdultDiabetes mellitusDiabetes MellitusOdds RatioPrevalenceMedicineHumanseducationArsenic0105 earth and related environmental scienceseducation.field_of_studyintegumentary systembusiness.industryConfoundingGeneral MedicineOdds ratioEnvironmental ExposureMiddle Agedmedicine.diseasePollution030104 developmental biologychemistrySeafoodSpainEnvironmental PollutantsFemaleArsenobetainebusinessEnvironmental pollution (Barking, Essex : 1987)
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The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control st…

2015

Background Abdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interaction between antioxidant vitamin intake and OS-related polymorphisms modulates gene-associated anthropometry in a Spanish population. Methods A total of 246 subjects with AO, and 492 age and gender matched non-AO subjects were included in the study. Anthropometric, biochemical, and OS parameters, and antioxidant dietary intake data were assessed using validated procedures. DNA from white blood cells was isolated and the genotype of seven polymorphisms from genes involved in …

MaleAntioxidantPolimorphismmedicine.medical_treatment:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Thioredoxins [Medical Subject Headings]Antioxidantes:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]AntioxidantsVitamin E intakeObesidad abdominalchemistry.chemical_compoundNutrigenomicsThioredoxinsPolymorphism (computer science):Anatomy::Cells::Blood Cells::Leukocytes [Medical Subject Headings]Risk FactorsGenotypeVitamin E:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleosides::Deoxyribonucleosides::Deoxyguanosine [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Micronutrients::Vitamins [Medical Subject Headings]:Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress [Medical Subject Headings]Abdominal obesityNutrigenómicaMedicine(all)AnthropometryAge FactorsGeneral MedicineAbdominal obesity:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity::Obesity Abdominal [Medical Subject Headings]Middle Aged:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models Statistical::Logistic Models [Medical Subject Headings]Waist circumferenceDietaFemale:Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]medicine.symptomFactores de riesgoVitaminAdultmedicine.medical_specialtyGenotypeVitamina ECatechol-O-methyltransferaseBiology:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes Reporter [Medical Subject Headings]Catechol O-Methyltransferase:Chemicals and Drugs::Biological Factors::Pigments Biological::Carotenoids::Retinoids::Vitamin A [Medical Subject Headings]Polymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologySex FactorsInternal medicine:Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Reactive Oxygen Species [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Antioxidants [Medical Subject Headings]medicinePerímetro abdominal:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Waist Circumference [Medical Subject Headings]:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 2-Ring::Benzopyrans::Vitamin E [Medical Subject Headings]HumansObesityPolymorphismThioredoxinAgedCatechol-O-methyl transferaseBiochemistry Genetics and Molecular Biology(all)Vitamin EResearchCase-control studyGenes informadores:Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics::Nutrigenomics [Medical Subject Headings]DietOxidative StressEndocrinologychemistrySpainOxidative stressCase-Control Studies:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::One-Carbon Group Transferases::Methyltransferases::Catechol O-Methyltransferase [Medical Subject Headings]:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::DNA [Medical Subject Headings]Genotipo
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Polymorphisms in endothelin system genes, arsenic levels and obesity risk.

2015

Background/objectivesObesity has been linked to morbidity and mortality through increased risk for many chronic diseases. Endothelin (EDN) system has been related to endothelial function but it can be involved in lipid metabolism regulation: Receptor type A (EDNRA) activates lipolysis in adipocytes, the two endothelin receptors mediate arsenic-stimulated adipocyte dysfunction, and endothelin system can regulate adiposity by modulating adiponectin activity in different situations and, therefore, influence obesity development. The aim of the present study was to analyze if single nucleotide polymorphisms (SNPs) in the EDN system could be associated with human obesity.Subjects/methodsWe analyz…

MaleEspañaObesidad:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Fat Distribution::Adiposity [Medical Subject Headings]Endothelins:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]:Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Endothelins [Medical Subject Headings]Polymorphism (computer science)Risk Factors:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity [Medical Subject Headings]:Chemicals and Drugs::Inorganic Chemicals::Elements::Arsenic [Medical Subject Headings]:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]education.field_of_studyMultidisciplinary:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings]Genètica humanaEndothelinsQRMiddle AgedPrognosisReceptor Endothelin APolimorfismo de nucleótido único:Anatomy::Cells::Connective Tissue Cells::Adipocytes [Medical Subject Headings]ObesitatMedicineFemaleTomografía computarizada por rayos X:Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]Endothelin receptor:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Image Interpretation Computer-Assisted::Tomography X-Ray Computed [Medical Subject Headings]Research Articlemedicine.hormonemedicine.medical_specialtyGenotype:Phenomena and Processes::Mathematical Concepts::Probability::Risk [Medical Subject Headings]SciencePopulationSingle-nucleotide polymorphism:Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism::Lipolysis [Medical Subject Headings]BiologyPolymorphism Single NucleotideArsenicReceptores de endotelinasInternal medicineAdipocitos:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Membrane Proteins::Receptors Cell Surface::Receptors Peptide::Receptors Endothelin [Medical Subject Headings]medicineHumansGenetic Predisposition to DiseaseObesityeducation:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic::Polymorphism Single Nucleotide [Medical Subject Headings]AdiponectinHaplotypeEnfermedad crónicamedicine.diseaseObesityEndocrinologyHaplotypesSpain:Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Adipokines::Adiponectin [Medical Subject Headings]GenotipoFollow-Up StudiesArsénicoPLoS ONE
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Enhanced reduction in oxidative stress and altered glutathione and thioredoxin system response to unsaturated fatty acid load in familial hypercholes…

2014

Abstract Objectives Familial hypercholesterolemia (FH) is characterized by increased oxidative stress (OS) levels. In the postprandial state, lipids and lipoproteins modulate OS status through their impact on pro-oxidant and antioxidant mechanisms. The objective of this study was to evaluate in patients with FH the response to an unsaturated oral fat load test (OFLT) by analyzing the mRNA levels of genes involved in the glutathione and thioredoxin antioxidant systems. Design and Methods We analyzed 14 FH patients and 20 normolipidemic and normoglycemic controls. In both groups, mRNA values of antioxidant enzyme genes (glutathione and thioredoxin systems) were determined at baseline and at 2…

AdultMalemedicine.medical_specialtyGPX1Antioxidantmedicine.medical_treatmentGlutamate-Cysteine LigaseClinical Biochemistrymedicine.disease_causeGPX4Gene Expression Regulation EnzymologicGlutathione SynthaseHyperlipoproteinemia Type IIchemistry.chemical_compoundThioredoxinsDietary Fats UnsaturatedInternal medicinemedicineHumansUnsaturated fatty acidGlutathione PeroxidaseChemistryReverse Transcriptase Polymerase Chain ReactionGeneral MedicineGlutathioneFastingMiddle AgedPhospholipid Hydroperoxide Glutathione PeroxidaseGlutathioneOxidative StressPostprandialEndocrinologyGlutathione ReductaseFemaleThioredoxinOxidation-ReductionOxidative stressClinical biochemistry
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Polymorphisms of the UCP2 gene are associated with body fat distribution and risk of abdominal obesity in Spanish population

2011

Eur J Clin Invest 2011 Abstract Background  Increased accumulation of fat results from an imbalance between energy expenditure and intake, being modulated by different environmental and genetic factors. Uncoupling proteins (UCPs) are mitochondrial carrier proteins able to spend energy generating heat. Therefore, variations in these genes are good candidates as potential modulators of body fat accumulation. Our aim was to investigate the possible association of genetic variations of the gene codifying the UCP2 protein with obesity and fat distribution. Design  We performed a cross-sectional study in 2367 individuals from two population-based studies from different regions of Spain. The Horte…

medicine.medical_specialtyeducation.field_of_studyWaistClinical BiochemistryPopulationGeneral MedicineBiologymedicine.diseaseBiochemistryObesityEndocrinologyInternal medicineGenetic variationGenotypemedicinemedicine.symptomeducationGeneAbdominal obesityBody fat distributionEuropean Journal of Clinical Investigation
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Plasma selenium levels and oxidative stress biomarkers: a gene-environment interaction population-based study.

2014

The role of selenium exposure in preventing chronic disease is controversial, especially in selenium-repleted populations. At high concentrations, selenium exposure may increase oxidative stress. Studies evaluating the interaction of genetic variation in genes involved in oxidative stress pathways and selenium are scarce. We evaluated the cross-sectional association of plasma selenium concentrations with oxidative stress levels, measured as oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8-oxo-7,8-dihydroguanine (8-oxo-dG) in urine, and the interacting role of genetic variation in oxidative stress candidate genes, in a representative sample of 1445 men and women…

inorganic chemicalsAdultMalemedicine.medical_specialtyCandidate geneAdolescentGenotypechemistry.chemical_elementUrinemedicine.disease_causeBiochemistrychemistry.chemical_compoundSeleniumYoung AdultPhysiology (medical)Internal medicineMalondialdehydemedicineHumansGene–environment interactionAgedGlutathione DisulfideChemistryfood and beveragesDeoxyguanosineGlutathioneMiddle AgedMalondialdehydeGlutathioneOxidative StressEndocrinologyCross-Sectional StudiesBiochemistry8-Hydroxy-2'-DeoxyguanosineSpainBiomarker (medicine)FemaleGene-Environment InteractionOxidative stressSeleniumBiomarkersFree radical biologymedicine
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Polymorphisms in the SCD1 gene are associated with indices of stearoyl CoA desaturase activity and obesity: a prospective study.

2013

Scope The serum fatty acid (FA) composition is influenced by dietary fat and the endogenous production of FAs. Stearoyl CoA desaturase 1 (SCD1) is the rate-limiting enzyme catalyzing the synthesis of MUFAs from saturated FAs. Variations in SCD1 activity have been associated with obesity, diabetes, or inflammation. We evaluated the associations between genetic variation of the SCD1 gene, SCD1 activity, intake of oil, and obesity in a population-based prospective study in southern Spain. Methods and results We collected phenotypic, metabolic, nutritional, and genetic information. The type of dietary fat was assessed from samples of cooking oil taken from the participants’ kitchens and analyze…

AdultMalemedicine.medical_specialtyPopulationSingle-nucleotide polymorphismBiologyPolymorphism Single NucleotideInternal medicineGenetic variationmedicineHumansPlant OilsGenetic Predisposition to DiseaseCookingObesityProspective StudieseducationOlive OilPhospholipidschemistry.chemical_classificationeducation.field_of_studyFatty acidMiddle Agedmedicine.diseaseObesityDietary FatsEnzyme assayStearoyl-CoA DesaturaseEndocrinologyBiochemistrychemistryHaplotypesSpainbiology.proteinlipids (amino acids peptides and proteins)Stearoyl-CoA desaturase-1Stearoyl-CoA DesaturaseFood ScienceBiotechnologyMolecular nutritionfood research
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The first wave of the Spanish COVID-19 epidemic was associated with early introductions and fast spread of a dominating genetic variant

2020

The COVID-19 pandemic has shaken the world since the beginning of 2020. Spain is among the European countries with the highest incidence of the disease during the first pandemic wave. We established a multidisciplinar consortium to monitor and study the evolution of the epidemic, with the aim of contributing to decision making and stopping rapid spreading across the country. We present the results for 2170 sequences from the first wave of the SARS-Cov-2 epidemic in Spain and representing 12% of diagnosed cases until 14th March. This effort allows us to document at least 500 initial introductions, between early February-March from multiple international sources. Importantly, we document the …

0303 health sciences03 medical and health sciences2019-20 coronavirus outbreak0302 clinical medicineGeographyCoronavirus disease 2019 (COVID-19)Research councilSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Genetic variantsLibrary science030212 general & internal medicine030304 developmental biology3. Good health
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