0000000000311486

AUTHOR

Julien P. Dupuis

showing 2 related works from this author

Co-activation of VEGF and NMDA receptors promotes synaptic targeting of AMPA receptors

2016

Vascular Endothelial Growth Factor A0301 basic medicineVEGF receptorsAMPA receptorHippocampusReceptors N-Methyl-D-Aspartate030226 pharmacology & pharmacy03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicinemedicineAnimalsDementiaReceptorMolecular BiologyNeuronsbiologyChemistrySynapsinsmedicine.diseasePsychiatry and Mental health030104 developmental biologySchizophreniaSynapsesBehavioral medicinebiology.proteinNMDA receptorPsychopharmacologyDisks Large Homolog 4 ProteinNeuroscienceMolecular Psychiatry
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A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior

2016

Vascular endothelial growth factor (VEGF) is known to be required for the action of antidepressant therapies but its impact on brain synaptic function is poorly characterized. Using a combination of electrophysiological, single-molecule imaging and conditional transgenic approaches, we identified the molecular basis of the VEGF effect on synaptic transmission and plasticity. VEGF increases the postsynaptic responses mediated by the N-methyl-D-aspartate type of glutamate receptors (GluNRs) in hippocampal neurons. This is concurrent with the formation of new synapses and with the synaptic recruitment of GluNR expressing the GluN2B subunit (GluNR-2B). VEGF induces a rapid redistribution of Glu…

Vascular Endothelial Growth Factor A0301 basic medicine[SDV]Life Sciences [q-bio]Cell Culture TechniquesNonsynaptic plasticityBiologyNeurotransmissionHippocampusReceptors N-Methyl-D-AspartateSynaptic TransmissionMice03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicinePostsynaptic potentialAnimalsddc:610Molecular BiologyComputingMilieux_MISCELLANEOUSNeuronsNeuronal PlasticityBehavior AnimalGlutamate receptorExcitatory Postsynaptic PotentialsKinase insert domain receptorFearVascular Endothelial Growth Factor Receptor-2Protein SubunitsPsychiatry and Mental health030104 developmental biologySynaptic fatigueReceptors GlutamateSynapsesSynaptic plasticityNMDA receptorOriginal ArticleNeuroscience030217 neurology & neurosurgery
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