RAGE Mediates a Novel Proinflammatory Axis

S100/calgranulin polypeptides are present at sites of inflammation, likely released by inflammatory cells targeted to such loci by a range of environmental cues. We report here that receptor for AGE (RAGE) is a central cell surface receptor for EN-RAGE (extracellular newly identified RAGE-binding protein) and related members of the S100/calgranulin superfamily. Interaction of EN-RAGEs with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Blockade of EN-RAGE/RAGE quenches delayed-type hypersensitivity and inflammatory colitis in murine models by arresting activation of central signaling pathw…

Difficulties in extracting spatial information induce a bias towards the use of non-spatial heuristics in a spatial memory task: Poster

Difficulties in extracting spatial information induce a bias towards the use of non-spatial heuristics in a spatial memory task: Oral presentation