0000000000316155

AUTHOR

Xavier Molero

showing 6 related works from this author

Evidence-based Guidelines for the Management of Exocrine Pancreatic Insufficiency After Pancreatic Surgery

2016

Objective: To provide evidence-based recommendations for the management of exocrine pancreatic insufficiency (EPI) after pancreatic surgery. Background: EPI is a common complication after pancreatic surgery but there is certain confusion about its frequency, optimal methods of diagnosis, and when and how to treat these patients. Methods: Eighteen multidisciplinary reviewers performed a systematic review on 10 predefined questions following the GRADE methodology. Six external expert referees reviewed the retrieved information. Members from Spanish Association of Pancreatology were invited to suggest modifications and voted for the quantification of agreement. Results: These guidelines analyz…

medicine.medical_specialtyEvidence-based practicediagnosisMEDLINEGuidelines030230 surgeryGastroenterologyPancreatic surgerysurgery03 medical and health sciencesPostoperative Complications0302 clinical medicineInternal medicineparasitic diseasesmedicineHumansGuidelines Management Exocrine Pancreatic Insufficiency Pancreatic SurgerypancreasguidelinesExocrine pancreatic insufficiencyPancreatic SurgeryConfusionpancreatic exocrine insufficiencyEvidence-Based Medicinetreatmentbusiness.industryPancreatic DiseasesEvidence-based medicinemedicine.diseaseManagementSurgerySpainpancreaticPractice Guidelines as TopicExocrine Pancreatic Insufficiency030211 gastroenterology & hepatologySurgerymedicine.symptomComplicationOptimal methodsbusinessAnnals of Surgery
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The Spanish Pancreatic Club's recommendations for the diagnosis and treatment of chronic pancreatitis: part 2 (treatment).

2012

Chronic pancreatitis (CP) is a complex disease with a wide range of clinical manifestations. This range comprises from asymptomatic patients to patients with disabling symptoms or complications. The management of CP is frequently different between geographic areas and even medical centers. This is due to the paucity of high quality studies and clinical practice guidelines regarding its diagnosis and treatment. The aim of the Spanish Pancreatic Club was to give current evidence-based recommendations for the management of CP. Two coordinators chose a multidisciplinary panel of 24 experts on this disease. These experts were selected according to clinical and research experience in CP. A list o…

medicine.medical_specialtyPancreatic pseudocystEndocrinology Diabetes and MetabolismExocrine pancreatic insufficiencyMEDLINENutritional StatusDiseaseConstriction PathologicGuidelinesPancreatitis ChronicPancreatic PseudocystDiagnosismedicinePain ManagementPancreatitis chronicIntensive care medicineExocrine pancreatic insufficiencyAcetaminophenCholangiopancreatography Endoscopic RetrogradeEvidence-Based MedicineHepatologybusiness.industryAnti-Inflammatory Agents Non-SteroidalGastroenterologyEvidence-based medicinemedicine.diseaseSurgeryPancreatic fistulaPancreatitisDrainageExocrine Pancreatic InsufficiencyTherapybusiness
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Standards not that standard

2015

There is a general assent on the key role of standards in Synthetic Biology. In two consecutive letters to this journal, suggestions on the assembly methods for the Registry of standard biological parts have been described. We fully agree with those authors on the need of a more flexible building strategy and we highlight in the present work two major functional challenges standardization efforts have to deal with: the need of both universal and orthogonal behaviors. We provide experimental data that clearly indicate that such engineering requirements should not be taken for granted in Synthetic Biology. Electronic supplementary material The online version of this article (doi:10.1186/s1303…

Environmental EngineeringStandardizationOrthogonality (programming)Requirements engineeringComputer scienceBiomedical EngineeringExperimental dataCell BiologyData scienceStandardizationSynthetic biologyWork (electrical)Key (cryptography)Registry of Standard Biological PartsBiobrick partsOrthogonalityLetters to the EditorMolecular BiologySynthetic biologyJournal of Biological Engineering
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Autophagy

2012

Klionsky, Daniel J. et al.

autophagy assays[SDV]Life Sciences [q-bio]AutolysosomeAutophagosome maturationautophagosomeBioinformaticsstressChaperone-mediated autophagyModelsLC3MESH: Animalsguidelinesautolysosome autophagosome flux LC3 lysosome phagophore stress vacuoleSettore BIO/06 - Anatomia Comparata E CitologiaComputingMilieux_MISCELLANEOUSSettore BIO/17Autophagy databaseautolysosome3. Good healthddc:540lysosomeEnergy and redox metabolism Mitochondrial medicine [NCMLS 4]methods [Biological Assay]Biological AssaySettore BIO/17 - ISTOLOGIANeuroniMAP1LC3BHumanautophagygenetics [Autophagy]AutofagiaMESH: Autophagy*/genetics[SDV.BC]Life Sciences [q-bio]/Cellular BiologyAutofagia; Neuroni; istologiaBiologyModels BiologicalLC3; autolysosome; autophagosome; flux; lysosome; phagophore; stress; vacuoleddc:570AutophagyAnimalsHumansAutophagy-Related Protein 7[SDV.BC] Life Sciences [q-bio]/Cellular BiologyBiological Assay/methodsMolecular BiologyBiologyAutophagy; guidelines; autophagy assaysistologiaphagophoreMESH: HumansAnimals; Biological Assay; Humans; Models Biological; AutophagyvacuoleAnimal[ SDV.BC ] Life Sciences [q-bio]/Cellular BiologyMESH: Models BiologicalPathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1]Cell BiologyBiologicalAutophagy/geneticsfluxAutophagosome membraneAutophagy Protein 5Human medicineMESH: Biological Assay/methods*Neuroscienceautolysosome; autophagosome; flux; LC3; lysosome; phagophore; stress; vacuoleAutophagy
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Recomendaciones del Club Español Pancreático para el diagnóstico y tratamiento de la pancreatitis crónica: parte 2 (tratamiento).

2013

Chronic pancreatitis (CP) is a complex disease with a wide spectrum of clinical manifestations ranging from asymptomatic disease to disabling forms or serious complications. The management of CP frequently differs among geographical areas and even among centers. These differences are due to the scarcity of high-quality studies and clinical practice guidelines that focus on the diagnosis and treatment of this disease. The aim of the Spanish Pancreatic Club was to create evidence-based recommendations for the management of CP. Two coordinators chose a multidisciplinary panel of 24 experts in this disease. These experts were selected on the basis of their clinical and research experience in CP…

medicine.medical_specialtyHepatologybusiness.industryGeneral surgeryGastroenterologyMEDLINEEvidence-based medicineDiseasemedicine.diseaseAsymptomaticPancreatic fistulamedicinePortal hypertensionPancreatitismedicine.symptombusinessExocrine pancreatic insufficiency
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Additional file 1: Table S1. of Standards not that standard

2015

Biobrick parts (Bb1 to Bb6) included in the different DNA constructions tested in this work. Table S2. Proteins displaying statistically significant alterations in their expression levels, as detected by iTRAQ analysis (DOCX 18 kb).

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