0000000000318985

AUTHOR

F Rinaldi

showing 4 related works from this author

Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone

2011

none 25 no Abstract OBJECTIVES: To evaluate the incidence and dose-dependency of mitoxantrone (MTX)-associated acute myelocytic leukemia (AML) in the network of Italian multiple sclerosis (MS) clinics. METHODS: We performed a multicenter retrospective cohort study of patients treated with MTX in MS centers under the Italian national health care system between 1998 and 2008. Demographic, disease, treatment, and follow-up information were collected using hospital records. RESULTS: Data were available for 3,220 patients (63% women) from 40 Italian centers. Follow-up (mean ± SD) was 49 ± 29 months (range 12-140 months). We observed 30 cases of AML (incidence 0.93% [95% confidence interval 0.60%…

Malemedicine.medical_specialtyMyeloidmitoxantrone; acute myelocytic leukemia; multiple sclerosisPopulationmultiple sclerosisStatistics NonparametricmitoxantroneFollow-Up StudieArts and Humanities (miscellaneous)Retrospective StudieInternal medicineMultiple SclerosimedicineHumansmultiple sclerosis leukemia mitoxantroneProspective cohort studyeducationRetrospective StudiesAgedAnalgesicseducation.field_of_studyMitoxantroneCumulative dosebusiness.industryMultiple sclerosisIncidence (epidemiology)leukemiaMyeloid leukemiaRetrospective cohort studymedicine.diseaseConfidence intervalSurgeryLeukemiaLeukemia Myeloid Acutemedicine.anatomical_structureItalyCohortSettore MED/26 - NeurologiaAnalgesicFemaleNeurology (clinical)acute myelocytic leukemiaMitoxantronebusinessFollow-Up Studiesmedicine.drugHuman
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Ultrasonographic and radionuclide detection of hepatocellular carcinoma in cirrhotics with low alpha-fetoprotein levels

1984

A total of 67 cirrhotic patients with clinically suspected neoplastic degeneration and low alpha-fetoprotein levels were assessed prospectively with ultrasound and gold (198Au) scintigraphy. Ultrasound showed space-occupying lesions in 22 of the 24 patients who had a final diagnosis of hepatocellular carcinoma (HCC) (sensitivity, 95.8%) and excluded the presence of HCC in 37 of the 43 patients with cirrhosis only (specificity, 86.0%; efficiency, 90.8%). Scintigraphy demonstrated a cold defect in 22 of the 24 patients who had a final diagnosis of HCC (sensitivity, 95.8%) and excluded the presence of HCC in 22 of the 43 patients with cirrhosis only (specificity, 51.1%; efficiency, 69.8%). It …

Cancer Researchmedicine.medical_specialtyAlpha fetoprotein levelsCirrhosismedicine.diagnostic_testbusiness.industryHepatobiliary diseaseUltrasoundmedicine.diseaseScintigraphyGastroenterologydigestive system diseasesOncologyInternal medicineHepatocellular carcinomaBiopsyMedicineRadiologyUltrasonographybusinessCancer
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Ultrasonography and alpha-fetoprotein in diagnosis of hepatocellular carcinoma in cirrhosis

1988

The accuracy of ultrasound (US) and alpha-fetoprotein (AFP) in the diagnosis of hepatocellular carcinoma (HCC) in 363 patients with cirrhosis (C) and a clinical suspicion of HCC was assessed. The ultrasonographic patterns of HCC and their relationship with AFP values were analyzed. Echographic patterns were distributed as follows: 47 patients had sonodense lesions; 30 patients had hypoechoic lesions; 47 had mixed-pattern lesions, and in four patients focal dilated intrahepatic bile ducts were demonstrated. The sensitivity of US was 90%; specificity was 93.3%. Serum AFP level greater than or equal to 500 ng/ml (RIA) was the first clue to the diagnosis in 71 patients (48.6%); specificity was …

Liver CirrhosisMalemedicine.medical_specialtyPathologyCarcinoma HepatocellularCirrhosisPhysiologySensitivity and SpecificityGastroenterologyTransplant surgeryDilated intrahepatic bile ductsInternal medicineHumansMedicineFalse Positive ReactionsProspective StudiesFalse Negative ReactionsneoplasmsUltrasonographybusiness.industryLiver NeoplasmsUltrasoundGastroenterologyHepatologymedicine.diseasedigestive system diseasesHepatocellular carcinomaFemalealpha-FetoproteinsUltrasonographybusinessAlpha-fetoproteinAlgorithmsDigestive Diseases and Sciences
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Immunoblotting as a confirmatory test for antimitochondrial antibodies in primary biliary cirrhosis.

1993

Primary biliary cirrhosis is characterised by the presence of antimitochondrial antibodies which are directed against components of mitochondrial dehydrogenase complexes. The specificity of antimitochondrial antibodies for primary biliary cirrhosis as detected by immunoblotting was investigated. Commercially available preparations of pyruvate and oxo-glutarate dehydrogenases and beef-heart mitochondria were used as source of antigens. Sera from 47 primary biliary cirrhosis patients (46 of whom were antimitochondrial antibody positive by immunofluorescence), 16 non-primary biliary cirrhosis patients (antimitochondrial antibody positive by immunofluorescence), 23 liver-kidney microsomal antib…

Adultmedicine.medical_specialtyPathologyBiliary cirrhosisImmunoblottingFluorescent Antibody TechniquePyruvate Dehydrogenase ComplexBiologyImmunofluorescenceGastroenterologyMitochondria HeartPrimary biliary cirrhosisAntigenAntibody SpecificityInternal medicinemedicineAnimalsHumansKetoglutarate Dehydrogenase ComplexAutoantibodiesHepatitismedicine.diagnostic_testLiver Cirrhosis BiliaryGastroenterologyAutoantibodyMiddle AgedPyruvate dehydrogenase complexmedicine.diseaseMitochondriabiology.proteinCattleFemaleAntibodyResearch ArticleGut
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