0000000000320697
AUTHOR
Maria Catanzaro
Unsupervised clustering method for pattern recognition in IIF images
Autoimmune diseases are a family of more than 80 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. Diagnosis of autoimmune pathologies is based on research and identification of antinuclear antibodies (ANA) through indirect immunofluorescence (IIF) method and is performed by analyzing patterns and fluorescence intensity. We propose here a method to automatically classify the centromere pattern based on the grouping of centromeres on the cells through a clustering K-means algorithm. The described method was tested on a public database (MIVIA). The results of the test showed an Accuracy…
Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project.
International audience; Antinuclear antibodies (ANAs) are significant biomarkers in the diagnosis of autoimmune diseases in humans, done by mean of Indirect ImmunoFluorescence (IIF) method, and performed by analyzing patterns and fluorescence intensity. This paper introduces the AIDA Project (autoimmunity: diagnosis assisted by computer) developed in the framework of an Italy-Tunisia cross-border cooperation and its preliminary results. A database of interpreted IIF images is being collected through the exchange of images and double reporting and a Gold Standard database, containing around 1000 double reported images, has been settled. The Gold Standard database is used for optimization of …