0000000000320709

AUTHOR

Bianchi A

showing 3 related works from this author

Predictive factors of response to mTOR inhibitors in neuroendocrine tumours

2016

Medical treatment of neuroendocrine tumours (NETs) has drawn a lot of attention due to the recent demonstration of efficacy of several drugs on progression-free survival, including somatostatin analogs, small tyrosine kinase inhibitors and mTOR inhibitors (or rapalogs). The latter are approved as therapeutic agents in advanced pancreatic NETs and have been demonstrated to be effective in different types of NETs, with variable efficacy due to the development of resistance to treatment. Early detection of patients that may benefit from rapalogs treatment is of paramount importance in order to select the better treatment and avoid ineffective and expensive treatments. Predictive markers for th…

0301 basic medicineOncologyCancer ResearchmTOR inhibitorEndocrinology Diabetes and MetabolismNeuroendocrine tumorsAntineoplastic Agent0302 clinical medicineEndocrinologyNeuroendocrine tumoursneuroendocrine tumourTreatment resistanceMTOR inhibitorsTumorMedical treatmentTOR Serine-Threonine KinasesDiscovery and development of mTOR inhibitorsResponse to treatmentPatient managementDiabetes and MetabolismNeuroendocrine TumorsOncology030220 oncology & carcinogenesisResponse to treatmentNeuroendocrine TumorHumanMTOR inhibitors; Neuroendocrine tumours; Predictors; Response to treatment; Animals; Antineoplastic Agents; Biomarkers Tumor; Diagnostic Imaging; Humans; Neuroendocrine Tumors; Protein Kinase Inhibitors; TOR Serine-Threonine Kinases; Endocrinology Diabetes and Metabolism; Oncology; Endocrinology; Cancer ResearchDiagnostic Imagingmedicine.medical_specialtyProtein Kinase InhibitorEarly detectionpredictorAntineoplastic AgentsMTOR inhibitors; Neuroendocrine tumours; Predictors; Response to treatment; Endocrinology; Oncology; Cancer Research; Endocrinology Diabetes and MetabolismBiologyNO03 medical and health sciencesmTOR inhibitors; neuroendocrine tumours; predictors; response to treatment; Animals; Antineoplastic Agents; Biomarkers Tumor; Diagnostic Imaging; Humans; Neuroendocrine Tumors; Protein Kinase Inhibitors; TOR Serine-Threonine KinasesInternal medicineBiomarkers TumormedicineAnimalsHumansmTOR inhibitorsneuroendocrine tumourspredictorsresponse to treatmentProtein Kinase InhibitorsmTOR inhibitors neuroendocrine tumours predictors response to treatmentAnimalPredictorsmedicine.disease030104 developmental biologyImmunologyBiomarkersResource utilizationEndocrine-Related Cancer
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Pollen-induced allergic rhinitis in 1360 Italian children: comorbidities and determinants of severity

2013

BACKGROUND: Pollen-induced allergic rhinoconjunctivitis (AR) is highly prevalent and rapidly evolving during childhood. General practitioners may not be fully aware of the nature and severity of symptoms experienced by patients and might underestimate the prevalence of moderate or severe disease. Thus, the relevance of early diagnosis and intervention may be overlooked. OBJECTIVES: To investigate the severity of pollen-induced AR and its determinants in Italian children referred to allergy specialists and who had never received specific immunotherapy (SIT). METHODS: Children (age 4-18 yr) affected by pollen-induced AR who had never undergone SIT were recruited between May 2009 and June 2011…

MaleQuestionnairesAllergyPediatricsmultiple pollen sydromemultiple pollen syndromeBreastfeedingComorbidityAirborne allergenSurveys and QuestionnairesEpidemiologyPrevalenceImmunology and AllergyOutpatient clinicAge of OnsetChildConjunctivitis AllergicRhinitispan-allergens; multiple pollen syndrome; profilin; asthma; children; allergic rhinitis; epidemiology; italy; allergic conjunctivitisEnvironmental exposuremultiple pollen syndrome; Humans; profilin; Disease Progression; children; Child; Italy; Comorbidity; pan-allergens; Allergens; asthma; Male; Antigens Plant; Questionnaires; Age of Onset; Conjunctivitis Allergic; Skin Tests; epidemiology; Pollen; Child Preschool; Rhinitis Allergic Seasonal; allergic rhinitis; Early Diagnosis; allergic conjunctivitis; Female; PrevalenceAllergic conjunctivitisItalypan-allergensChild PreschoolpanallergenDisease ProgressionPollenepidemiologyFemaleallergic rhinitimedicine.medical_specialtyItaly; allergic conjunctivitis; allergic rhinitis; asthma; children; epidemiology; multiple pollen syndrome; pan-allergens; profilinImmunologyAllergicchildrenmedicineHumansprofilinallergic conjunctivitiAntigensPreschoolAsthmaSkin TestsSettore MED/38 - Pediatria Generale e SpecialisticaSeasonalallergic rhinitisbusiness.industryallergic rhinitis; allergic conjunctivitis; asthma; children; epidemiology; Italy; multiple pollen syndrome; pan-allergens; profilinRhinitis Allergic SeasonalPlantAntigens PlantAllergensasthmamedicine.diseaseConjunctivitispan-allergenallergic conjunctivitisEarly DiagnosisPediatrics Perinatology and Child Healthbusiness
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Endovascular treatment of CCSVI in patients with multiple sclerosis: clinical outcome of 462 cases

2013

Although it is still debated whether chronic cerebro-spinal venous insufficiency (CCSVI) plays a role in multiple sclerosis (MS) development, many patients underwent endovascular treatment (ET) of CCSVI. The objective of the study is to evaluate the outcome and safety of ET in Italian MS patients. Italian MS centers that are part of the Italian MS Study Group were all invited to participate to this retrospective study. A structured questionnaire was used to collect detailed clinical data before and after the ET. Data from 462 patients were collected in 33 centers. ET consisted of balloon dilatation (93 % of cases) or stent application. The mean follow-up duration after ET was 31 weeks. Mean…

AdultMalePediatricsmedicine.medical_specialtyMultiple Sclerosismedicine.medical_treatmentendovascular multiple sclerosis treatment venousDermatologyBalloon dilatationCohort StudiesSurveys and QuestionnairesMedicineHumansIn patientEndovascular treatmentAdverse effectBeneficial effectsbusiness.industryMultiple sclerosisEndovascular ProceduresStentBrainRetrospective cohort studyGeneral MedicineMiddle Agedmedicine.diseaseSurgeryPsychiatry and Mental healthTreatment OutcomeSpinal CordVenous InsufficiencySettore MED/26 - NeurologiaFemaleNeurology (clinical)businessMultiple sclerosis CCSVI Endovascular treatmentFollow-Up Studies
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