0000000000321142

AUTHOR

Joshua Miller

showing 2 related works from this author

Vascular complications following bladder drained, simultaneous pancreas-kidney transplantation: the University of Miami experience

2000

Vascular complications remain a significant nonimmunologic source of pancreas allograft loss. From February 1993 through January 1998, we performed 98 simultaneous pancreas-kidney transplantations (SPK) using pancreatic exocrine bladder drainage in patients with type 1 insulin-dependent diabetes mellitus and end-stage renal disease. They originally received quadruple immunosuppression, and since May 1997 triple immunosuppression protocol (tacrolimus, mycophenolate mofetil, and steroids). The patients' mean age was 37 years (range 24-53 years), including 50 women and 48 men with a mean follow-up of 42 months. The overall rate of vascular complications was 6% (5 patients). The vascular compli…

NephrologyAdultMalemedicine.medical_specialtyTime FactorsUrinary BladderArteriovenous fistulaHospitals UniversityPseudoaneurysmMesenteric VeinsPostoperative ComplicationsMesenteric Artery Superiormedicine.arteryInternal medicinemedicineHumansDiabetic NephropathiesSuperior mesenteric arteryVascular DiseasesSuperior mesenteric veinRetrospective StudiesVenous ThrombosisTransplantationbusiness.industryAnticoagulantsMiddle Agedmedicine.diseaseThrombosisKidney TransplantationSurgerymedicine.anatomical_structureDiabetes Mellitus Type 1Splenic veinFloridaKidney Failure ChronicDrug Therapy CombinationFemalePancreas TransplantationPancreasbusinessAneurysm FalseImmunosuppressive AgentsSpleenTransplant International
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Use of tacrolimus and mycophenolate mofetil as induction and maintenance in simultaneous pancreas-kidney transplantation

2000

Clinical trials using quadruple immunosuppression that include the combination of tacrolimus and mycophenolate mofetil have been shown to reduce the incidence of acute rejection episodes in simultaneous pancreas-kidney (SPK) transplantation. In an attempt to obtain a low rejection rate without antibody induction therapy, we undertook a prospective study of combined tacrolimus and mycophenolate mofetil and steroids as primary immunosuppression for SPK transplantation. In this study, we analyzed 17 patients who received low-dose intravenous tacrolimus as induction therapy. This was combined with oral tacrolimus, mycophenolate mofetil, and steroids as the primary immunosuppression regimen. The…

AdultGraft RejectionMaleNephrologymedicine.medical_specialtyBiopsymedicine.medical_treatmentUrinary Bladderchemical and pharmacologic phenomenaPancreas transplantationGastroenterologyTacrolimusMycophenolic acidInternal medicinemedicineHumansKidney transplantationTransplantationLeukopeniabusiness.industryImmunosuppressionMiddle AgedMycophenolic Acidmedicine.diseaseKidney TransplantationTacrolimusTransplantationsurgical procedures operativeDrug Therapy CombinationFemaleSteroidsPancreas Transplantationmedicine.symptombusinessmedicine.drugTransplant International
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