New injectable depot systems based on alpha,beta-poly(N-2-hydroxyethyl)-D,L-aspartammide copolymers

PHOTOCROSSLINKING OF DEXTRAN AND POLYASPARTAMIDE DERIVATIVES: A COMBINATION SUITABLE FOR COLON- SPECIFIC DRUG DELIVERY.

The aim of this study was to prepare and characterize novel hydrogels with polysaccharide–polyaminoacid structure, able to undergo an enzymatic hydrolysis in the colon and potentially useful for treating inflammatory bowel diseases (IBD). Starting materials were methacrylated dextran (DEX-MA) and methacrylated α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHM). These polymers were photocrosslinked by exposure of their aqueous solutions at 313 nm without photoinitiators. Different samples, shaped as microparticles, were obtained as a function of polymer concentration and irradiation time. FT-IR analysis confirmed the occurrence of a co-crosslinking between DEX-MA and PHM in all experimental con…

Bioadhesive disk based on photo-crosslinkable polyaspartamide derivative for drug delivery

HYDROGELS BASED ON DEXTRAN AND POLYASPARTAMIDE METHACRYLIC DERIVATIVES

NEW PEGYLATED NANOPARTICLE SYSTEMS BASED ON POLYASPARTAMIDE DERIVATIVES

PREPARATION AND IN VITRO CHARACTERIZATION OF NEW HYDROGELS BASED ON INULIN AND ALPHA,BETA-POLYASPARTYLHYDRAZIDE FOR COLONIC DRUG DELIVERY

POLYMERIC SUPRAMOLECULR SYSTEMS FOR PROTEIN DELIVERY