0000000000323036

AUTHOR

Steven B. Abramson

showing 2 related works from this author

Author response: Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

2013

ImmunologyPrevotella coprimedicineArthritisBiologymedicine.disease
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Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis.

2013

Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models suggest a role for intestinal bacteria in supporting the systemic immune response required for joint inflammation. Here we performed 16S sequencing on 114 stool samples from rheumatoid arthritis patients and controls, and shotgun sequencing on a subset of 44 such samples. We identified the presence of Prevotella copri as strongly correlated with disease in new-onset untreated rheumatoid arthritis (NORA) patients. Increases in Prevotella abundance correlated with a reduction in Bacteroides and a loss of reportedly beneficial microbes in NORA subjec…

AdultMalerheumatoidQH301-705.5SciencePrevotellaArthritismicrobiomemedicine.disease_causeGeneral Biochemistry Genetics and Molecular BiologyMicrobiologyAutoimmunityPathogenesisArthritis Rheumatoid03 medical and health sciencesMice0302 clinical medicineImmune systemmedicinePrevotellaBacteroidaceae InfectionsAnimalsHumansMicrobiomeBiology (General)030304 developmental biology030203 arthritis & rheumatology0303 health sciencesmetagenomicsGeneral Immunology and MicrobiologybiologyGeneral NeuroscienceautoimmunityQRGeneral Medicinemedicine.diseasebiology.organism_classification3. Good healthMice Inbred C57BLDisease Models AnimalarthritisinflammationRheumatoid arthritisImmunologyMedicineFemaleBacteroidesGenome BacterialeLife
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