0000000000324141

AUTHOR

Klaus Schwarz

showing 2 related works from this author

DIETETIC HEPATIC INJURIES AND THE MODE OF ACTION OF TOCOPHEROL

1949

History and Philosophy of ScienceAction (philosophy)business.industryGeneral NeuroscienceMedicineTocopherolPharmacologybusinessGeneral Biochemistry Genetics and Molecular BiologyAnnals of the New York Academy of Sciences
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High-resolution HLA matching in hematopoietic stem cell transplantation: a retrospective collaborative analysis.

2013

To validate current donor selection strategies based on previous international studies, we retrospectively analyzed 2646 transplantations performed for hematologic malignancies in 28 German transplant centers. Donors and recipients were high resolution typed for HLA-A, -B, -C, -DRB1, and -DQB1. The highest mortality in overall survival analysis was seen for HLA-A, -B, and DRB1 mismatches. HLA-DQB1 mismatched cases showed a trend toward higher mortality, mostly due to HLA-DQB1 antigen disparities. HLA incompatibilities at >1 locus showed additive detrimental effects. HLA mismatching had no significant effect on relapse incidence and primary graft failure. Graft source had no impact on surviv…

AdultMaleMultivariate analysisAdolescentmedicine.medical_treatmentImmunologyGraft vs Host DiseaseHematopoietic stem cell transplantationHuman leukocyte antigenHLA-C AntigensBiochemistry03 medical and health sciencesYoung Adult0302 clinical medicineimmune system diseasesTransplantation ImmunologyGermanymedicineHLA-DQ beta-ChainsHumansAlleleSurvival rateSurvival analysis030304 developmental biologyAgedRetrospective Studies0303 health sciencesHLA-A AntigensDonor selectionbusiness.industryHistocompatibility TestingHazard ratioHematopoietic Stem Cell TransplantationCell BiologyHematologyMiddle AgedSurvival AnalysisTissue Donors3. Good healthSurvival RateHLA-B AntigensHematologic NeoplasmsHistocompatibilityImmunologyMultivariate AnalysisFemalebusiness030215 immunologyHLA-DRB1 ChainsBlood
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